Safety of paracetamol and tramadol for perioperative analgesia of total knee arthroplasty

doi:10.3969/j.issn.2095-4344.2015.44.010

Abstract

Abstract:

BACKGROUND: The function was poor in middle aged and elderly patients with total knee replacement. If there was no ideal anesthesia during the operation, the prognosis of patients would be poor. Therefore, it is necessary to explore the analgesic drugs for artificial knee joint arthroplasty.
OBJECTIVE: To investigate clinical analgesic efficacy of tramadol and paracetamol in total knee arthroplasty and the drug safety.
METHODS: 200 cases undergoing unilateral total knee arthroplasty in the Department of Orthopedics of Huaian First Hospital Affiliated to Nanjing Medical University from December 2013 to January 2015 were enrolled in this study. According to the different methods of analgesia, patients were divided into control and experimental groups, with 100 cases in each group. Control group received intravenous patient controlled analgesia. Experimental group received paracetamol and tramadol orally. Clinical analgesic efficacy and safety of tramadol paracetamol in total knee arthroplasty were analyzed.
RESULTS AND CONCLUSION: No significant difference in visual analogue scale score was detected immediately, 4 and 5 days after replacement in both groups. Visual analogue scale score was significantly lower in the experimental group than in the control group at 1-3 days after replacement. Hospital for Special Surgery scores at 7 and 12 months after replacement and Special Surgery scores at 24 and 72 hours after replacement were significantly higher in the experimental group than in the control group. The twice doses of tramadol and paracetamol were significantly lower at 24 and 48 hours after replacement in the experimental group than in the control group. The incidence of complications was significantly lower in the experimental group than in the control group. These data verify that during perioperative analgesia, the effects of tramadol and paracetamol were ideal, could lessen patient’s pain, contribute to the recovery of knee function, have less adverse reactions, and have a certain clinical application value.
中国组织工程研究杂志出版内容重点：人工关节；骨植入物；脊柱；骨折；内固定；数字化骨科；组织工程

Key words: Analgesics, Knee Prosthesis, Arthroplasty, Replacement, Knee, Tissue Engineering

Liu Yan. Safety of paracetamol and tramadol for perioperative analgesia of total knee arthroplasty[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(44): 7103-7107.

Figures/Tables 4

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