Dexmedetomidin relieves inflammatory response in the aged patients after hip replacement

doi:10.3969/j.issn.2095-4344.2015.44.005

Abstract

Abstract:

BACKGROUND: Hip replacement surgery is a common surgery in elderly patients. Regulatory effect of dexmedetomidin on inflammatory response in the aged patients after hip replacement attracted more and more attention.

OBJECTIVE: To observe the effects of dexmedetomidin on inflammatory response in aged patients undergoing hip replacement, and to provide theoretical reference for inflammatory sedation.

METHODS: 100 elderly patients aged from 60 to 75 years with hip replacement surgery were randomly divided into control group and observation group (n=50). The control group intravenously received midazolam injection. The observation group received dexmedetomidin injection. Changes in inflammatory markers, such as C-reactive protein, tumor necrosis factor-α and leukocyte count and Ramsay sedation score changes were compared and observed between the two groups before replacement (T0), 24 hours (T1) and 48 hours (T2) after replacement.

RESULTS AND CONCLUSION: Leukocyte level presented an increased trend in both groups at T1. C-reactive protein and tumor necrosis factor-α levels decreased, and no significant difference was detected between the two groups (P > 0.05). At T2, leukocyte levels were significantly increased in the observation group (P < 0.05), and leukocyte levels were gradually returned to T0 level in the control group. C-reactive protein and tumor necrosis factor-α levels were lower at T2 than at T1 in both groups (P < 0.05). However, the decreased degree was bigger in the observation group than in the control group. Ramsay sedation score was significantly higher in the observation group than in the control group at T1 and T2 (P < 0.01). These findings indicate that dexmedetomidine for sedation after hip replacement can lessen inflammatory response and contribute to the recovery of hip function.
中国组织工程研究杂志出版内容重点：人工关节；骨植入物；脊柱；骨折；内固定；数字化骨科；组织工程

Key words: Dexmedetomidine, Arthroplasty, Replacement, Hip, Inflammation, Tissue Engineering

Song Hai-ming, Ma Jing-hua, Chen Hui. Dexmedetomidin relieves inflammatory response in the aged patients after hip replacement[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(44): 7077-7081.

Figures/Tables 5

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