High-dose methylprednisolone sodium succinate therapy for acute spinal cord injury in adults: a Meta-analysis

doi:10.3969/j.issn.2095-4344.2015.42.027

Abstract

Abstract:

BACKGROUND: Some control studies attempt to answer the advantages and disadvantages of high-dose methylprednisolone sodium succinate therapy for acute spinal cord injury in adults, but have arrived at different conclusions.

OBJECTIVE: To explore the therapeutic efficacy of high-dose methylprednisolone sodium succinate therapy on acute spinal cord injury in adults by Meta analysis.

METHODS:PubMed, Embase, Cochranel Library, CBMdisc, VIP and WanFang Databases were searched by computer, and relevant Chinese and English orthopedic journals were retrieved by hand. Controlled trials related to high-dose methylprednisolone sodium succinate therapy of acute spinal cord injury in adults were included. The methodology quality of included trials was critically assessed. RevMan 5.0 software was used for data analysis.

RESULTS AND CONCLUSION: Nine clinical controlled trials were included. Meta-analysis results showed that compared with the conventional therapy, the neurological recovery rate after 24 hours of administration, pneumonia incidence and gastrointestinal reactions increased significantly after high-dose methylprednisolone sodium succinate therapy. However, there were no statistical differences in the rate of urinary tract infection, nonunion rate and stress ulcer incidence between these two therapies. These findings indicate that the high-dose methylprednisolone sodium succinate therapy on acute spinal cord injury in adults has better outcomes in neurological function recovery, but can lead to higher incidence of lung infection and gastrointestinal reactions. Therefore, lung infection and gastrointestinal reactions should be avoided as much as possible during the course of treatment.
中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Methylprednisolone, Spinal Cord Injuries, Hormones

Liu Xiang-dong, Wang Lei, Dong Zhe, Ma Yan-hui, Hu Fang, Ma Gai-ping, Wang Feng-feng,Yang Sheng-jun . High-dose methylprednisolone sodium succinate therapy for acute spinal cord injury in adults: a Meta-analysis[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(42): 6875-6881.

Figures/Tables 8

References

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