Methods for establishing rat models of spinal cord injury: a meta-analysis

doi:10.3969/j.issn.2095-4344.0561

Abstract

Abstract:

BACKGROUND: A safe and effective spinal cord injury rat model with high clinical similarity is important for the studies on changes in the pathophysiology and anatomy of spinal cord injury. There are various modeling methods, so choosing which one still remains controversial.

OBJECTIVE: To compare the efficacy and mortality of various models of spinal cord injury contusion type, compression type, ischemic injury type, and transverse type using a meta-analysis so as to provide evidence for establishing rat models of spinal cord injury.

METHODS: Databases of PubMed, CNKI, VIP and WanFang were searched for the literature concerning spinal cord injury modeling methods published before March 11, 2018. The literature screening and data extraction were conducted. Mesh analysis was performed on Stata and Winbug software to obtain the efficacy results.

RESULTS AND CONCLUSION: A total of 17 eligible articles were included, involving 506 Sprague-Dawley rats. The order of the effectiveness of spinal cord injury model was as follows: transverse > contusion > compression > ischemic injury. The order of mortality was as follows: transverse > contusion > compression > ischemic injury.

Key words: Spinal Cord Injuries, Models, Animal, Tissue Engineering

CLC Number:

R318

Wei Weibing, Zhou Binbin, Li Bolin, Qin Jingyu, Feng Zhenfen, Li Jiannan. Methods for establishing rat models of spinal cord injury: a meta-analysis[J]. Chinese Journal of Tissue Engineering Research, 2019, 23(12): 1949-1954.

Figures/Tables 4

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