The regulating effect of N-methyl-D-aspartate receptor on neural synaptic plasticity in a rat model of chronic cerebral ischemia

doi:10.3969/j.issn.2095-4344.2015.40.019

Abstract

Abstract:

BACKGROUND: N-methyl-D-aspartate receptor is an ionic glutamate receptor which is closely related with the neural synaptic plasticity, and also can regulate neural synaptic plasticity.

OBJECTIVE: To explore the mechanism by which N-methyl-D-aspartate receptor subunits NR2A and NR2B regulate neural synaptic plasticity after cerebral ischemia.

METHODS: 60 Wister rats were randomly and evenly divided into a sham-operated group and a cerebral ischemia group. Rat models of chronic cerebral ischemia were established using the modified bilateral common carotid artery occlusion method in the cerebral ischemia group, while rats in the sham-operated group did not undergo occlusion of the common carotid artery and vagus nerve.

RESULTS AND CONCLUSION: At 0-12 hours after chronic cerebral ischemia, NR2A expression in the rat hippocampus was gradually decreased, while the expression of NR2B reached its peak level at 4 hours after cerebral ischemia. Under the circumstance of cerebral ischemia, neither low frequency nor high frequency induced long-term potentiation. These findings suggest that NR2B exhibit inhibitory effect, while NR2A exhibit promoting effect on long-term potentiation induced by stimulation.

中国组织工程研究杂志出版内容重点：肾移植；肝移植；移植；心脏移植；组织移植；皮肤移植；皮瓣移植；血管移植；器官移植；组织工程

Key words: Receptor, NMDA, Long-term Potentiation, Cerebral Ischemia, Hippocampus

CLC Number:

R318

Wang Lu, Huo Shuai, Wang Ya-fei, Zhao Lin, Liu Bo-feng, Ruan Cai-lian, Hui Xue-feng. The regulating effect of N-methyl-D-aspartate receptor on neural synaptic plasticity in a rat model of chronic cerebral ischemia [J]. Chinese Journal of Tissue Engineering Research, 2015, 19(40): 6498-6503.

Figures/Tables 2

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