Osteochondral autograft and allograft and tissue engineering materials for repair of articular cartilage injury

doi:10.3969/j.issn.2095-4344.2015.34.023

Abstract

Abstract:

BACKGROUND: In recent years, repair of articular cartilage injury has become an important field in basic medical research. Because injured articular cartilage is difficult to repair, the repair of articular cartilage injury has become a difficult hotspot.

OBJECTIVE: To review the biomaterials possibly used for articular cartilage repair and functional reconstruction, thereby providing a theoretical basis for the selection of the desired tissue engineering scaffolds.

METHODS: The first author searched the PubMed and CNKI databases (1989-2014) using the keywords of “articular cartilage injury, bone graft, tissue engineering scaffold materials” in English and Chinese, respectively. Articles related to the structure and function of the articular cartilage and materials for repair of different articular cartilage injuries were selected to systematically review and summarize the materials for articular cartilage repair. Then, advantages and disadvantages of these repair materials were reviewed to introduce several kinds of cartilage repair materials applied as cartilage tissue engineering scaffolds from the perspective of materialogy, thus providing a theoretic basis for the clinical selection of cartilage repair materials.

RESULTS AND CONCLUSION: Commonly used cartilage repair materials include osteochondral autograft and allograft, collagen, sodium hyaluronate, chitosan and other natural polymer materials. Osteochondral autograft and allograft transplantation can be only used for temporary pain relief, but cannot repair the injured cartilage successfully. In addition, tissue engineering technology is in the research phase and its clinical research is ongoing. Either autograft materials or tissue-engineered scaffold materials have their own biomechanical properties, and up to now, it is still impossible to produce the artificial cartilage tissue that has the same mechanical properties to the natural cartilage tissues.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Osteoarthritis, Cartilage, Bone Transplantation, Tissue Engineering, Biocompatible Materials

CLC Number:

R318

Zhou Jian-lin, Fang Hong-song, Peng Hao, Deng Shuang, Weng Jin-qing, Liu Feng, Chen Sen, Zhou Guan-jin. Osteochondral autograft and allograft and tissue engineering materials for repair of articular cartilage injury [J]. Chinese Journal of Tissue Engineering Research, 2015, 19(34): 5530-5535.

Figures/Tables 2

References

[1] Beris AE, Lykissas MG, Papageorgiou CD, et al. Advances in articular cartilage repair. Injury. 2005;36 Suppl 4: S14-S23.
[2] Gobbi A, Nunag P, Malinowski K. Treatment of full thickness chondral lesions of the knee with microfracture in a group of athletes. Knee Surg Sports Traumatol Arthrosc. 2005;13(3): 213-221.
[3] Mano JF, Reis RL. Osteochondral defects: present situation and tissue engineering approaches. J Tissue Eng Regen Med. 2007;1(4):261-273.
[4] Wolfe MM, Lichtenstein DR, Singh G. Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs. N Engl J Med, 1999; 340(24):1888-1899.
[5] Kotz R, Kolarz G. Intra-articular hyaluronic acid: duration of effect and results of repeated treatment cycles. Am J Orthop (Belle Mead NJ). 1999;28(11 Suppl):5-7.
[6] Martin I, Miot S, Barbero A, et al. Osteochondral tissue engineering. J Biomech. 2007;40(4):750-765.
[7] Azuma Y, Ito M, Harada Y, et al. Low intensity pulsed ultrasound accelerates rat femoralfracture healing by acting on the various cellular reactions in the fracture callus. J Bone Miner Res. 2001;16(4):671-680.
[8] Hubbard MJ. Articular debridement versus washout for degeneration of the medial femoral condyle: a five-year study. J Bone Joint Surg Br. 1996;78(2):217-219.
[9] Knutsen G, Engebretsen L, Ludvigsen TC, et al. Autologous chondrocyte implantation compared with microfracture in the knee. A randomized trial. J Bone Joint Surg Am. 2004;86-A(3): 455-464.
[10] Jackson RW, Dieterichs C. The results of arthroscopic lavage and debridement ofosteoarthritic knees based on the severity of degeneration: a 4-to 6-year symptomaticfollow-up. Arthroscopy. 2003;19(1):13-20.
[11] Barber FA, Chow JC. Arthroscopic osteochondral transplantation: histologic results. Arthroscopy. 2001;17(8): 832-835.
[12] Buckwalter JA, Mankin HJ. Articular cartilage: tissue design and chondrocyte-matrix interactions. Instr Course Lect. 1998; 47:477-486.
[13] McCulloch PC, Kang RW, Sobhy MH, et al. Prospective evaluation of prolonged fresh osteochondral allograft transplantation of the femoral condyle. Am J Sports Med. 2007;35(3):411-420.
[14] Gross AE, Agnidis Z, Hutchison CR. Osteochondral defects of the talus treated with fresh osteochondral allograft transplantation. Foot Ankle Int. 2001;22(5)385-391.
[15] 郑荣宗,吴伟东,应锦河,等.关节镜下自体骨软骨移植治疗膝关节软骨缺损[J].中国骨与关节损伤杂志,2014,29(10):1050-1051.
[16] 张利恒,桑平,李光淳,等.关节镜下自体软骨移植修复中青年软骨缺损疗效观察[J].吉林医学,2008,29(23):2145-2146.
[17] Czitrom AA, Keating S, Gross AE. The viability of articular cartilage in fresh osteochondral allografts after clinical transplantation. J Bone Joint Surg Am. 1990;72(4)574-581.
[18] Steadman JR, Briggs KK, Rodrigo JJ,et al. Outcomes ofmicrofracturefor traumatic chondral defects of the knee: average 11-year follow-up. Arthroscopy. 2003;19(5):477-484.
[19] Willers C, Chen J, Wood D, et al. Autologous chondrocyte implantation with collagen bioscaffold for the treatment of osteochondral defects in rabbits. Tissue Eng. 2005;11(7-8): 1065-1076.
[20] Grande DA, Pitman MI, Peterson L, et al. The repair of experimentally produced defects in rabbit articular cartilage by autologous chondrocyte transplantation. J Orthop Res. 1989;7(2):208-218.
[21] Tratting S, Mamisch TC, Pinker K, et al. Differentiating normal hyaline cartilage from post-surgical repair tissue using fast gradient echo imaging in delayed gadolinium-enhanced MRI (dGEMRIC) at 3 Tesla. Eur Radiol. 2008;18(6):1251-1259.
[22] Marcacci M, Zaffagnini S, Kon E, et al. Arthroscopic autologous chondrocyte transplantation: technical note. Knee Surg Sports Traumatol Arthrosc. 2002;10(3):154-159.
[23] Brittberg M, Lindahl A, Nilsson A, et al. Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. New Eng J Med. 1994;331(14):889-895.
[24] Hoemann CD, Hurtig M, Rossomach E, et al. Chitosan-glycerol phosphate/blood implants improve hyaline cartilage repair in ovine microfracture defects. J Bone Joint Surg Am. 2005;87(12):2671-2686.
[25] 周程沛,曹安,方春抒,等.新鲜自体与异体骨软骨移植修复免关节软骨缺损的比较义[J].中国组织工程研究与临床康复,2009, 13(15):2833-2836.
[26] Chevrier A, Hoemann CD, Sun J, et al. Chitosan-glycerol phosphate-blood implants increase cell recruitment, transient vascularisation and subchondral bone remodeling in drilled cartilage defects. Osteoarthritis Cartilage. 2007;15(3): 316-327.
[27] Peterson L, Minas T, Brittberg M, et al. Two- to 9-year outcome after autologous chondrocyte transplantation of the knee. Clin Orthop Relat Res. 2000;(374):212-234.
[28] Fragonas E, Valente M, Pozzi-Mucelli M, et al. Articular cartilage repair in rabbits by using suspensions of allogenic chondrocytes in alginate. Biomaterials. 2000;21(8):795-801.
[29] Bartlett W, Skinner JA, Gooding CR, et al. Autologous chondrocyte implantation versusmatrix-induced autologous chondrocyte implantation for osteochondral defects of the knee: aprospective, randomised study. J Bone Joint Surg Br. 2005;87(5):640-645.
[30] Almqvist KF, Dhollander AA, Verdonk PC, et al. Treatment of cartilage defects in the knee using alginate beads containing human mature allogenic chondrocytes. Am J Sports Med. 2009;37(10):1920-1929.
[31] 项舟,胡炜,孔清泉,等.骨髓间充质干细胞种植Ⅰ型胶原支架材料修复关节软骨缺损的初步研究[J].中国修复重建外科杂志,2006, 20(2):148-154.
[32] Madsen BL, Noer HH, Carstensen JP, et al. Long-term results of periosteal transplantation in osteochondritis dissecans of the knee. Orthopedics. 2000;23(3):223-226.
[33] Kim MS, Hwang NS, Lee J, et al. Musculoskeletal differentiation of cells derivedfrom human embryonic germ cells. Stem Cells. 2005;23(1):113-123.
[34] 崔运利,王富友,谭洪波,等.利用胶原和聚乙烯醇构建组织工程软骨支架[J].第三军医大学学报,2010,32(17):1820-1823.
[35] 朱凌云,王彦平,石宗利,等.聚磷酸钙纤维/明胶软骨组织工程支架复合材料的制备及性能表征[J].中国组织工程研究与临床康复,2010,9(47):9265-9268.
[36] Veilleux N, Spector M. Effects of FGF-2 and IGF-1 on adult canine articularchondrocytes in type II collagen-glycosaminoglycan scaffolds in vitro. Osteoarthritis Cartilage. 2005;13(4):278-286.
[37] Saha K, Pollock JF, Schaffer DV, et al. Designing synthetic materials to control stem cell phenotype. Curr Opin Chem Biol. 2007;11(4):381-387.
[38] Li WJ, Tuli R, Okafor C, et al. A three-dimensional nanofibrous scaffold for cartilagetissue engineering using human mesenchymal stem cells. Biomaterials. 2005;26(6):599-609.
[39] Grande DA, Mason J, Light E, et al. Stem cells as platforms for delivery of genes to enhance cartilage repair.J Bone Joint Surg Am. 2003;85-A Suppl 2:111-116.
[40] 刘少英,陈建英,陈倩倩,等.以交联透明质酸钠为支架体外构建组织工程软骨[J].中国组织工程研究,2014,(8):1191-1197.
[41] 刘春栋,张志光,苏凯,等.透明质酸改性聚乳酸支架组织工程软骨的构建[J].广东牙病防治,2012,20(3):124-129.
[42] Sato M, Ishihara M, Ishihara M, et al. Effects of growth factors on heparin-carrying polystyrene-coated atelocollagen scaffold for articular cartilage tissue engineering. J Biomed Mater Res B Appl Biomater. 2007;83(1):181-188.
[43] 杨强,彭江,卢世璧,等.新型脱细胞软骨基质三维多孔支架的制备[J].中国修复重建外科杂志,2008,3:359-363.
[44] Nishida T, Kubota S, Kojima S, et al. Regeneration of defects in articular cartilage in rat knee joints by CCN2 ( connective tissue growth factor). J Bone Miner Res. 2004;19(8):1308-1319.
[45] Aoyama E, Hattori T, Hoshijima M, et al. N-terminal domains of CCN family 2 /connective tissue growth factor bind to aggrecan. Biochem J. 2009;420(3):413-420.
[46] 郭忠鹏,彭超,蒋电明,等.三种生物材料修复兔关节软骨缺损的性能对比[J].中国组织工程研究与临床康复,2010,16:2870-2874.
[47] 瞿桂友.壳聚糖制作组织工程软骨支架的研究[J].大家健康(中旬版),2013,(10):195-196.
[48] 夏万尧,曹谊林,商庆新,等.壳聚糖作为组织工程软骨支架的实验研究[J].中华显微外科杂志,2002,25(1):34-37.
[49] Okano H, Tomita N, Ikada Y, et al. Effects of 120 mT static magnetic field on TGF-beta1-inhibited endothelial tubular formation in vitro. Bioelectromagnetics. 2007;28(6):497-499.
[50] Madry H, Zurakowski D, Trippel SB. Overexpression of human insulin-like growth factor-I promotes new tissue formation in an ex vivo model of articular chondrocyte transplantation. Gene Ther. 2001;8(19):1443-1449.
[51] Oligino T, Ghivizzani S, Wolfe D, et al. Intra-articular delivery of a herpes simplex virus IL-1Ra gene vector reduces inflammation in a rabbit model of arthritis. Gene Ther. 1999;6(10):1713-1720.
[52] 林荔军,朱立新,丁超,等.BMP-6改良纤维蛋白原支架软骨模块修复兔关节软骨缺损的实验研究[J].实用预防医学,2008, 15(4):994-996.
[53] Kwon GY, Jeong J, Woo JK, et al. Co-expression of bfl-1 enhances host response in the herpes simplex virus-thymidine kinase/ganciclovir gene therapy system. Biochem Biophys Res Commun. 2003;303(3):756-763.