OPG-RANKL-RANK signaling system is an important approach to regulate osteoclasts and osteoporosis

doi:10.3969/j.issn.2095-4344.2015.24.023

Abstract

Abstract:

BACKGROUND: The OPG-RANKL-RANK transport system plays a crucial role in bone resorption mechanism of osteoclasts.
OBJECTIVE: To observe the expression of OPG-RANKL-RANK signaling system in osteoclasts, osteoporosis, and the targeted therapy of OPG-RANKL-RANK signaling system.
METHODS: We retrieved related literatures in the periodicals database with the key words of “osteoprotegerin, RANKL, RANK, osteoclasts, osteoporosis” in English and Chinese. According to the inclusion criteria, the literatures were included in this study after the evaluation of quality.
RESULTS AND CONCLUSION: The mature of osteoclasts is mediated via OPG-RANKL-RANK signaling system and its associated signaling pathways. This signal pathway leads to the mechanism of osteoporosis. At the genetic and molecular levels, the targeted therapy of osteoporosis has become the focus. OPG-RANKL-RANK signaling system can provide a research platform for targeted treatment of osteoporosis, and OPG-RANKL-RANK signaling system is an important way to the regulation of osteoclasts and osteoporosis.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Osteoporosis, RANK Ligand, Osteoprotegerin, Osteoclasts

CLC Number:

R318

Li Yan-long, He Ming, Chen Bing-xiong, Chen Bing-hu, Wang Jun-xia, Wang Tian-xue, Wei Hong, Song Min. OPG-RANKL-RANK signaling system is an important approach to regulate osteoclasts and osteoporosis [J]. Chinese Journal of Tissue Engineering Research, 2015, 19(24): 3894-3898.

Figures/Tables 1

References

[1] 何伟,张俐,王维佳等,骨病的临床研究[M].北京:科技出版社,2006：322-323

[2] 韩金祥,骨分子生物学[M].北京:科学出版社,2010:275-283

[3] Tanaka S.Signaling axis in osteoclast biology and therapeutic targeting in RANKL/RANK/OPG,system.Am J Nephrol.2007；27(5):466-478.

[4] Simonet WS,Lacey DL,Dunstan C，et al.Osteoprotegerin:A novel secreted protein involved in the regulation of bone density.Cell.1997;89(2):309-319.

[5] Tuysuz B,Mizumoto S,Sugahara K,et al.Omani-type spondyloepiphyseal dysplasia with cardiac involvement caused by a missense mutation in CHST3.Clinical Genetics. 2009;75(4):375-383.

[6] van Roij MH,Mizumoto S,Yamada K,et al.Spondyloepiphyseal dysplasia,Omani type:further definition of the phenotype.Am J Med Genet.2008;146A(18):2376-2384.

[7] Greene ND,Stanier P,Copp AJ.Genetic of human neural tube defects.Human Molecular Genetics.2009;18(R2):R113-129.

[8] Leskela HV,Kuorilehto T,Risteli J,et al.Congenital pseudarthrosis of neurofibromatosis type1:impaired osteoblast differentiation and function and altered NF1 gene expression.Bone.2009；44(2):243-250

[9] Shrimpton AE,Levinsohn EM,Yozawitz JM,et al.A HOX gene mutation in a family with isolated congenital vertical talus and Charcot-Marie-Tooth disease.Am J Hum Genet.2004;75(1): 92-96.

[10] Boyce BF,Xing L.Biology of RANK,RANKL,and osteoprotegerin.Arthritis Res Ther.2007;9(Supp1 1):S1

[11] Yang X,Halladay D,Onyia JE,et al.Protein Kinase C is a mediator of the synthesis and secretion of osteoprotegerin in osteoblast-like cells.Biochem Bioph is Res Commun. 2002; 290(1):42-46.

[12] Lacey DL,Tan HL,Liu I,et al.Osteoprotegerin ligand modulates murine osteoclast survival in nitro and in vivo.Am J Pathol. 2000; 157(2):435-448.

[13] 孔祥鹤,牛银波,李宇华等.OPG-RANKL-RANK系统与骨质疏松研究最新进展[J].生命科学研究.2011,15(1):80-85.

[14] Joseph DJ,Ichikawa S,Econs MJ.Mosaicism in Osteopathia Striata with Cranial Sclerosis. J Clin Endocrinol Metab. 2010;95(4):1506-1507.

[15] Anne K,Sundeep K,Paul K.RANK and OPG regulation of bone remodeling in health and disease.Endocrine Reviews. 2008; 29(2):155-192.

[16] 仲蕾蕾,杨冰,黄晓斌，等. OPG/RANKL/RANK系统在成骨细胞和破骨细胞相互调节中的作用[J].中国骨质疏松杂志,2011, 17(11): 1010-1013.

[17] Kulkarni RN,Bakker AD,Everts V,et al.Inhibition of osteoclastogenesis by mechanically loaded osteocytes: involvement of MEPE.Caleif Tissue Int.2010;87(5): 461-468.

[18] 梁文娜,李四海,李灿东,等.骨免疫与绝经后骨质疏松妇女骨重建失衡[J].国际骨科学杂志,2012,33(2):103-105.

[19] Syed FA,Fraser DG,Monroe DG,et al.Distinct effects of loss of classical estrogen receptor signaling versus complete deletion of estrogen receptor alpha on bone.Bone.2011;49(2): 208-216.

[20] Somjen D,Katzburg S,Sharon O,et al.The effects of estrogen receptorsаand βspecific agonists and antagonists on cell proliferation and energy metabolism in human bone cell line.J Cell Biochem.2011;112(2):625-632.

[21] Miranda-Carboni GA,Guemes M,Bailey S,et al.GATA4 regulates estrogen receptor-alpha-mediated osteoblast transcription.Mol Endocrinol.2011;25(7):1126-1136.

[22] 高延征,高坤,沈彬,等.去卵巢后大鼠骨组织中核因子κB受体活化因子配体和骨保护素表达的变化[J].中国组织工程研究与临床康复, 2009,13(15):2877-2881.

[23] 魏劲松,王键,龚颜,等. 去卵巢大鼠骨代谢及骨髓细胞 OPG、RANKL基因表达的实验研究[J].中国骨质疏松杂志,2013,19(3): 207-211.

[24] 褚建国,王季军.骨质疏松骨代谢的OPG/RANKL/RANK作用机制[J].中国老年学杂志,2013,20(33):5015-5017.

[25] 刘敏燕,成晓玲,李春霖,等.不同骨质疏松风险的男性人群骨定量超声及骨密度分析[J].中华老年医学杂志,2013,32(2):191-194.

[26] 徐晓东,邓洋洋,郑洪新.糖皮质激素诱导肾虚骨质疏松症大鼠骨组织中OPG/RANKLmRNA蛋白表达的影响[J].中华中医药学刊, 2013,31(12):2623-2627.

[27] Drescher W,Weigert KP,Bunger MH,et al.Femoral head blood flow reduction and hypercoagulability under 24h megadose steroid treatment in pigs.J Orthop Res.2008;22(3):501-508.

[28] Bateman TA,Dunstan CR.Osteoprotegerin mitigate stail suspension induced osteopenia.Bone.2000;26(3):443-449.

[29] Sanchez C,Gabay O,Salvat C,et al.Mechanical loading highly increase IL-6production and decrease OPG expression by osteoblasts.Ostoarthritis Cartilage.2009;17(4):473-481.

[30] Iglesias-Linares A,Moreno-Fernandez AM.The use of gene therapy vs corticotomy surgery in accelerating orthodontic tooth movement.Orthod Craniofac Res.2011;14(3):138-148.

[31] Ellis GK,Bone HG,Chlebowski R,et al.Effect of denosumab on bone mineral density in women receiving adjuvant aromatase inhibitors for non-metastatic breast cancer:subgroup analyses of aphase 3 study.Breast Cancer Res Treat.2009;118(1): 81-87.

[32] Kostenuik PJ,Nguyen HQ,Mccabe J,et al.Denosumab,a fully human monoclonal antibody to RANKL,inhibits bone resorption and increases BMD in knock-in mice that express chimeric (murine/human)RANKL.J Bone Miner Res.2009；24(2):182-195.