Collagen sponge as an artificial dura mater combined with ozone to repair brain injury

doi:10.3969/j.issn.2095-4344.2015.21.005

Abstract

Abstract:

BACKGROUND: The integrity of the dura mater is very important for prognosis of patients with brain injury prognosis. Artificial dura mater is a commonly repair material, and to look for an ideal artificial dura mater is the exploration direction in the neurosurgery field.
OBJECTIVE: To observe and analyze the clinical data of brain injury patients undergoing repair of collagen sponge as dura mater substitute material with ozone therapy, and to explore and evaluate its clinical value.
METHODS: Follow-up results of therapeutic efficacy and complications in 60 cases of brain injury following repair with collagen sponge artificial dura mater and ozone treatment were retrospectively analyzed.
RESULTS AND CONCLUSION: Two patients died of postoperative diffuse brain swelling, one died of brain injury with multiple organ failures, and two cases of extensive brain injury accompanied by cerebral herniation were in vegetative state. The rest 55 patients were enrolled in the final analysis. After surgery, two patients appeared to have postoperative subcutaneous fluid and their conditions improved following puncture aspiration and pressure dressing with elastic bandage; another patient showed a small amount of subdural effusion, but did not undergo special treatment, and dynamic head CT showed the effusion was gradually reduced. Cranial CT examination showed no abnormalities associated with the artificial dura mater. At 3-6 months after surgery, the artificial dura mater was fused well with the normal dura mater in 28 cases undergoing skull patching, and there was no adhesion and inflammatory reaction. Taken together, the collagen sponge artificial dura mater with ozone can give full play to the decompression treatment of traumatic brain injury, which can maintain the brain function, shorter operative time, result in fewer complications, and have good compatibility, and moreover, the artificial dura mater can be fused well with the normal dura to protect the brain cortex, thereby providing favorable conditions for the latter skull repair.

Key words: Biocompatible Materials, Histocompatibility, Collagen, Ozone

CLC Number:

R318

Qu Hong, Zhao Ming-guang, Liang Ying, Zhao Li-ping, Li Xiao-hong, Wang Ying. Collagen sponge as an artificial dura mater combined with ozone to repair brain injury[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(21): 3302-3308.

Figures/Tables 4

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