Dexmedetomidine effects on hemodynamic changes and cognitive ability of elderly patients undergoing lumbar surgery

doi:10.3969/j.issn.2095-4344.2015.11.027

Abstract

Abstract:

BACKGROUND: Commonly used anesthetics have some impacts on perioperative hemodynamics and cognitive function of elderly patients. Dexmedetomidine is reported to have high affinity with adrenergic receptors, and maybe has less hemodynamic effects.

OBJECTIVE: To observe the effects of dexmedetomidine on hemodynamics and cognitive function in elderly patients undergoing anesthesia in lumbar surgery.

METHODS: Ninety patients with American Society of Anesthesiologists I-II scheduled for lumbar surgery, aged over 60 years, were selected and randomly divided into three groups, 30 cases in each group. Patients in three groups were respectively treated with 0.5, 1.0 μg of 1.0 μg/kg dexmedetomidine and the same volume of normal saline (control group) after anesthesia induction with midazolam 0.04 mg/kg+fentanyl 5 ug/kg+Victoria Cool bromide 0.1 mg/kg. Sedation assessment, forgotten degree, hemodynamic stability in anesthesia intubation, and postoperative cognitive function were compared between three groups.

RESULTS AND CONCLUSION: There were significant differences in the auditory evoked potential between the three groups at 5 and 10 minutes after administration (P < 0.05), and the auditory evoked potential was significantly lower in the 1.0 μg group than the 0.5 μg and control groups as well as significantly lower in the 0.5 μg group than the control group. At 10 minutes after administration, the scores on modified Observer’s assessment of alterness/sedation were significantly lower in the 1.0 μg group than the 0.5 μg and control groups (P < 0.05). Compared with the control group, the systolic pressure was significantly higher in the 1.0 and 0.5 μg groups at 5, 10, 20, 30, 60 minutes after administration as well as the diastolic pressure was significantly higher in the 1.0 and 0.5 μg groups at different time after administration (P < 0.05). The incidence of postoperative cognitive impairment was significantly lower in the 1.0 μg group than the

0.5 μg group (P < 0.05). Experimental findings show that under general anesthesia, dexmedetomidine is propitious to hemodynamic stability, improves the analgesic effect and reduces the incidence of postoperative cognitive impairment.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

全文链接：

Key words: Lumbar Vertebrae, Anesthesia, Analgesics

CLC Number:

R318

Xu Ya-feng, Song Ying-chun, Xu Fei. Dexmedetomidine effects on hemodynamic changes and cognitive ability of elderly patients undergoing lumbar surgery[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(11): 1788-1792.

Figures/Tables 4

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