Age difference of estrogen receptor gene polymorphisms in the elderly women with hip osteoporosis

doi:10.3969/j.issn.2095-4344.2015.07.002

Abstract

Abstract:

BACKGROUND: Since the age differences exist in gene polymorphism, the incidence of osteoporosis-induced systemic skeletal diseases is varied in different age groups.

OBJECTIVE: To investigate the age differences of estrogen receptor gene polymorphisms in the elderly women with hip osteoporosis.

METHODS: Seventy-two elderly women with hip osteoporosis were selected as osteoporosis group, and another 72 non-hip osteoporosis elderly women served as controls. There was no significant difference in age and diseases between two groups (P > 0.05). Simultaneously, PCR-RFLP at loci of Xba I and Pvu II and bone mineral density were analyzed and tested.

RESULTS AND CONCLUSION: The distribution rates of X and XX alleles were significantly higher in the osteoporosis group than the control group (P < 0.05). Patients with the XX genotype were significantly older than those with Xx and xx genotypes (P < 0.05). Logistic regression linear correlation analysis showed that the age was obviously correlated with the occurrence of hip osteoporosis in patients with XX genotypes (P < 0.05). These findings indicate that gene polymorphisms at XX locus of estrogen receptor gene have some influences on the occurrence of hip osteoporosis in elderly women, and there is the age-related distribution difference.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

全文链接：

Key words: Receptors, Estrogen, Genes, Hip, Osteoporosis, Aged

CLC Number:

R318

Wang Zeng-rong . Age difference of estrogen receptor gene polymorphisms in the elderly women with hip osteoporosis[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(7): 991-995.

Figures/Tables 5

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