Three-dimensional microarchitecture of the proximal femur in osteoarthritis and rheumatoid arthritis

doi:10.3969/j.issn.2095-4344.2015.07.003

Abstract

Abstract:

BACKGROUND: The main reason for reducing the life of joint prosthesis is prosthetic loosening. In addition to prosthesis design, surgical technique, prosthetic material and the resulting wear particles, bone quality also plays a very important role in prosthetic loosening. Bone tissue microstructure has an important impact on bone quality. Recently, the quantification of bone architecture based on micro-CT has been widely used in the research of various bone diseases.
OBJECTIVE: To observe the osteoarthritis- and rheumatoid arthritis-related changes in the properties of the proximal femur based on micro-CT, thus to compare the bone microstructure in osteoarthritis and rheumatoid arthritis patients.
METHODS: Femoral heads were collected from primary osteoarthritis (n=10) and rheumatoid arthritis (n=7) patients undergoing total hip replacement. A 10-mm segment of the femoral neck was cut from each individual femur, perpendicular to the main trabecular direction on X-ray films. The specimens were analyzed by using micro-CT system. After scanning, the data were transferred to three-dimensional images, and then detailed structural parameters of the cortical bone, cancellous bone and femoral neck were statistically analyzed based on novel unbiased, model-free three-dimensional methods.
RESULTS AND CONCLUSION: There was no significant difference in the microstructure of the femoral head (cortical bone, cancellous bone and the entire) between the primary osteoarthritis and rheumatoid arthritis groups. The overall microstructure properties of the femoral neck were similar to those of the cancellous bone. Primary osteoarthritis patients were characterized by a more loss of the connectivity to the trabecular bone, an increase in degree of anisotropy for the cortical bone, but a decrease in degree of anisotropy for the cancellous bone and the entire trabecular bone, when compared to the rheumatoid arthritis group. These findings show that there is no difference in the microstructure of the cortical bone, the cancellous bone and the entire femoral neck between patients with primary osteoarthritis and rheumatoid arthritis, suggesting that primary osteoarthritis and rheumatoid arthritis have a similar trend of global microarchitectural degeneration in the femoral neck.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Osteoarthritis, Hip, Arthritis, Rheumatoid, Femur Neck

CLC Number:

R318

Wang Bai-liang, Ming Ding, Søren Overgaard. Three-dimensional microarchitecture of the proximal femur in osteoarthritis and rheumatoid arthritis[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(7): 996-1002.

Figures/Tables 1

Difference in the three-dimensional microstructure of femoral neck specimens between osteoarthritis and rheumatoid arthritis groups All the data were not distributed normally. Analyses of variation in the microstructural properties of different regions in the two groups are summarized in Table 1. The patients with osteoarthritis were older than those with rheumatoid arthritis, but there was no significant difference. The entire cortical bone of the femoral neck in patients with rheumatoid arthritis had higher BV/TV, Co.Th*, Co.N* and Co.CD, lower Co.Sp, Co.DA and CSA than those with osteoarthritis, but there was no significant difference between the two groups. The entire trabecular bone in the rheumatoid arthritis group had higher BV/TV, Tb.N*, Tb.CD, Tb.DA and CSA, lower Tb.Th*, Tb.Sp than that in the osteoarthritis group, but there was no significant difference between the two groups. Properties of the femoral neck were similar to those of the trabecular bone. This decrease in bone volume in the osteoarthritis group resulted from the decreased amount of cortical and trabecular bone tissues as well as a consequent increase in dispersion degree. The osteoarthritis group was also characterized by a loss of the connectivity, an increase in DA for the cortical bone, but a decrease in DA for the cancellous bone and the entire trabecular bone when compared to the rheumatoid arthritis group. Relations between the microstructural parameters of femoral neck specimens in osteoarthritis and rheumatoid arthritis groups Among all the parameters, BV/TV had the strong correlation with Th*, Sp, SMI, and N* for the entire femoral head, cortical and trabecular bone in both osteoarthritis and rheumatoid arthritis groups. For all the three regions of rheumatoid arthritis and osteoarthritis patients, we found a BV/TV-related increase in Th* and a BV/TV-related decrease in Sp and SMI. But for the correlation between BV/TV and N*, there was no consistent tendency in the three regions of osteoarthritis and rheumatoid arthritis groups. The significant correlations between Sp and N* were also found in the three regions of osteoarthritis and rheumatoid arthritis groups. "

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