Different viral vectors in gene-enhanced bone tissue engineering

doi:10.3969/j.issn.2095-4344.2015.02.021

Abstract

Abstract:

BACKGROUND: Various gene-delivery strategies have be used to transfer targeted genes into damaged bone tissues. As the most efficient gene vector, viral delivery systems have been used in bone tissue engineering research.
OBJECTIVE: To thoroughly discuss the applications of different viral vectors in gene-enhanced bone tissue engineering.
METHODS: A computer-based online search was performed in PubMed database for the related articles from January 2002 to January 2015. This review centered on viral vector transduction methods and their use in bone tissue engineering. Adenovirus, retrovirus, adeno-associated virus and chimeric virus were all discussed. Advantages and limitations of different vectors and their applicability toward bone tissue engineering were presented in this article. A total of 24 articles were included for review.
RESULTS AND CONCLUSION: Current viral vectors for gene delivery in gene-enhanced bone tissue engineering are summarized, including recent work where combinatorial gene therapy is used to express groups of genes to stimulate bone regeneration. Future directions for this field are discussed, where viral vectors mediated gene expression systems will be combined with cells such as mesenchymal stem cells seeded in synthetic scaffolds to repair bone loss. Gene-enhanced bone tissue engineering has more advantages than traditional tissue engineering; viral vectors contribute to higher gene transfection efficiency than normal vectors. Long-term clinical observation is needed for the safety of viral vectors used in gene-enhanced tissue engineering in the body. Viruses are still the most efficient means by which exogenous genes can be introduced into seeds cells.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

全文链接：

Key words: Genes, Viruses, Gene Therapy

CLC Number:

R318

Xiao Zhen-tao, Guo Zhong-kai, Guo Li-xin . Different viral vectors in gene-enhanced bone tissue engineering[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(2): 272-276.

Figures/Tables 1

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