Granulocyte colony-stimulating factor induces osteogenesis

doi:10.3969/j.issn.2095-4344.2014.33.005

Abstract

Abstract:

BACKGROUND: Mesenchymal stem cells are a kind of adult stem cells with the potentials of self-replicating and multi-directional differentiation. Under certain conditions, the cells can develop into bone, cartilage and other types of cells. Granulocyte colony-stimulating factors can promote regeneration of mesenchymal stem cells.
OBJECTIVE: To observe the osteogenic induction effect of granulocyte colony-stimulating factors by animal experiment, and provide a better treatment method for clinical treatment of bone defect.
METHODS: Forty New Zealand rabbits were randomly divided into treatment group and model group. All animals were removed 2 cm length of the right radial bone and the surrounding periosteum, and then implanted with demineralized bone matrix into the defect. The treatment group was subcutaneously injected with granulocyte colony-stimulating factor 30 μg/kg per day, the injection was started at preoperative 3 days and given for 7 continuous days. In control group, the same dose of physiological saline was injected.
RESULTS AND CONCLUSION: In the treatment group, the number of mesenchymal stem cells, the quantity and quality of bone formation at bone defects were better than those in the model group. The experimental findings indicate that granulocyte colony-stimulating factor can obviously increase the number of mesenchymal stem cells and promote bone formation at the area of bone defect, which can contribute to early repair of bone defects.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

全文链接：

Key words: granulocyte colony-stimulating factor, mesenchymal stem cells, mesenchymal stem cell transplantation, radius

CLC Number:

R318

Zhang Bin, Lv Song-cen, Tao Shu-qing, Rong Jie-sheng. Granulocyte colony-stimulating factor induces osteogenesis[J]. Chinese Journal of Tissue Engineering Research, 2014, 18(33): 5276-5281.

Figures/Tables 5

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