Bone metabolism in patients with osteoporotic vertebral deformation

doi:10.3969/j.issn.2095-4344.2014.24.006

Abstract

Abstract:

BACKGROUND: Osteoporosis often leads to thoracolumbar deformation, since bone metabolism indicators are sensitive to reflect conversion process of individual bone, it can reduce misdiagnosis and predict fracture risk when combined with bone mineral density, thus early reducing the incidence of severe vertebral deformity.
OBJECTIVE: To analyze the significance of bone metabolism in patients with osteoporotic vertebral deformation.
METHODS: A total of 157 elderly patients with osteoporosis were divided into vertebral deformation group and normal vertebrae group according to the presence of vertebral deformation. In the vertebral deformation group, the patients were further assigned into normal bone mineral density subgroup and reduced bone mineral density subgroup. Bone mineral density and N-telopeptides of type I collagen, β-Crosslaps, osteocalcin were tested in each group. Finally we compared the differences of bone metabolism between each group.
RESULTS AND CONCLUSION: N-telopeptides of type I collagen, β-Crosslaps and osteocalcin in vertebral deformation group were higher than that in normal group (P < 0.05). N-telopeptides of type I collagen and β-Crosslaps in normal bone mineral density subgroup were higher than that in reduced bone mineral density subgroup (P < 0.05), there was no significant difference between the two subgroups (P > 0.05). The results showed that vertebral deformation group has a higher level of bone metabolism than normal group, normal bone mineral density subgroup expresses higher levels of N-telopeptides of type I collagen and β-Crosslap than reduced bone mineral density subgroup in vertebral deformation group. The higher level of bone metabolism combined with bone mineral density and vertebral deformation can contribute to diagnose osteoporosis and predict vertebral fragile fractures.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

全文链接：

Key words: osteoporosis, bone mineral density, spine

CLC Number:

R318

Gao Fei, Qiao Ju-feng, Gao Feng, Tang Qi, Mo Ji-xian, Li Ming-zhang. Bone metabolism in patients with osteoporotic vertebral deformation[J]. Chinese Journal of Tissue Engineering Research, 2014, 18(24): 3803-3807.

Figures/Tables 1

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