Application of the collagen sponge artificial dura in severe traumatic brain injury

doi:10.3969/j.issn.2095-4344.2014.08.026

Abstract

Abstract:

BACKGROUND: Craniotomy for severe traumatic brain injury is required to maintain the integrity of the dura mater. The artificial dura mater is now a common dural repair material, and looking for the ideal artificial dura mater is the exploring direction of neurosurgery.
OBJECTIVE: To explore the application of collagen sponge artificial dura in severe traumatic brain injury
METHODS: A retrospective analysis of 96 patients with severe head injury was performed, including 32 cases of the artificial dura with tightly suturing as the control group, and 64 cases of the artificial dura of collagen sponge without suturing as the experimental group. Operating time for hematoma clearance, blood loss, postoperative mechanical ventilation time, ICU monitoring time, the total number of hospitalized days as well as time interval from hematoma clearance to cranioplasty, operative time for cranioplasty, blood loss, and Glasgow Coma Scale scores after dural damage and 6 months postoperatively in the two groups were measured.
RESULTS AND CONCLUSION: The same purpose was achieved in the two groups. The amount of bleeding during hematoma clearance, postoperative mechanical ventilation time, monitoring time in ICU, the total number of hospitalized days and Glasgow Coma Scale score of 6 months postoperatively showed no significant difference between the two groups (P > 0.05). But operative time for hematoma clearance and cranioplasty as well as blood loss in the second operation were statistically significant between two groups (P < 0.05). The collagen sponge artificial dura in severe traumatic brain injury can fully play a good role in reducing intracranial pressure, keeping brain functions, shortening operative time, and improving outcomes of patients, which has similar effects to tightly suturing the dura and creates favorable conditions for the following cranioplasty.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

全文链接：

Key words: biocompatible materials, collagen, craniocerebral trauma, neural prostheses

CLC Number:

R318

Qin Guo-qiang, Wang Guan, Yan Cheng-fen, Peng Cai-zu, Shi Bo, Huang Wei-min. Application of the collagen sponge artificial dura in severe traumatic brain injury[J]. Chinese Journal of Tissue Engineering Research, 2014, 18(8): 1307-1312.

Figures/Tables 4

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