Chinese Journal of Tissue Engineering Research ›› 2014, Vol. 18 ›› Issue (8): 1161-1164.doi: 10.3969/j.issn.2095-4344.2014.08.003

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Biological properties of biphasic tricalcium phosphate bioceramics/calcium sulfate bone cement porous three-dimensional scaffolds  

Tan Ying-yun1, Bai Shi1, Liao Yun-mao2   

  1. 1Department of Dental Implantation, Stomatological Hospital Affiliated to Chongqing Medical University, Chongqing 400015, China; 2State Key Laboratory of Oral Diseases, Chengdu 610041, Sichuan Province, China
  • Received:2013-12-06 Online:2014-02-19 Published:2014-02-19
  • Contact: Bai Shi, Master, Attending physician, Department of Dental Implantation, Stomatological Hospital Affiliated to Chongqing Medical University, Chongqing 400015, China
  • About author:Tan Ying-yun, Master, Physician, Department of Dental Implantation, Stomatological Hospital Affiliated to Chongqing Medical University, Chongqing 400015, China

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Abstract:

BACKGROUND: With the development of tissue engineering, porous bioceramics are more and more used to repair bone defects. Current research focuses on the biological synthesis of this bioceramics and its performance evaluation.
OBJECTIVE: To discuss the preparation of a new kind of bone cement and to determine its physicochemical properties and biocompatibility with osteoblasts.
METHODS: Biphasic tricalcium phosphate powders were prepared using co-precipitation method. The powder was turned into granular stuff by arabic gum. After sintering, porous hydroxyapatite/tricalcium phosphate bioceramics were harvested, and then mixed with alpha-hemihydrate to prepare the bone  
cement.
RESULTS AND CONCLUSION: X-ray diffraction confirmed that the synthetic substance was a kind of biphasic calcium phosphate ceramic having a porous structure. The bone cement could be in the plastic state within      3 minutes. The curing time was 15 minutes, and the curing temperature was 36.5 ℃. The maximum compression strength was 5.82 MPa, and the MTT toxicity was level 0. Osteoblasts could grew well on the material surface.


中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程


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Key words: biocompatible materials, calcium sulfate, hydroxyapatites, osteoblasts

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