Toothpaste containing NovaMin is applied to treat dentine hypersensitivity

doi:10.3969/j.issn.2095-4344.2013.38.022

Abstract

Abstract:

BACKGROUND: NovaMin is a kind of bioactive glass, and its active ingredients react with saliva to form hydroxyapatite crystals, which deposit on the surface of the teeth and can close the exposed dentinal tubules. It can be used for the treatment of dentin hypersensitivity.
OBJECTIVE: To study the effect of toothpaste containing NovaMin on tooth hypersensitivity patients after subgingival scaling and root planing surgery.
METHODS: According to inclusion and exclusion criteria, 96 patients were picked out from 543 patients to participate in the experiment. In compliance with the principle of randomized, double-blind, comparison, 98 subjects were randomly divided into two groups: experiment group in which the toothpaste containing NovaMin was used, and control group in which the toothpaste without NovaMin was used. Visual analog scale scoring was used to evaluate the degree of sensitivity to air stimulus respectively before and 4 weeks after allergy experiment.
RESULTS AND CONCLUSION: Totally 88 patients completed the experiment. After treatment with toothpaste for 4 weeks, visual analog scale scores in the experiment group decreased from 4.25±1.87 at baseline to 2.53±1.22 by air stimulus, and visual analog scale scores in the control group decreased from 4.03±1.92 at baseline to 3.63±1.45. The visual analog scale scores in the experiment group and control group both reduced, and the difference was with statistics significance (P < 0.05). Compared with the control group, visual analog scale scores in the experiment group decreased more significantly. It showed that the toothpaste containing NovaMin has significant effect on dentin hypersensitivity after subgingival scaling and root planing surgery.

Key words: biocompatible materials, dentin, dentin sensitivity, glass

CLC Number:

R318

Li Chan-xiu, Huang Jiang-yong, Liang Huan-you. Toothpaste containing NovaMin is applied to treat dentine hypersensitivity[J]. Chinese Journal of Tissue Engineering Research, doi: 10.3969/j.issn.2095-4344.2013.38.022.

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References

[1] Addy M. Dentine hypersensitivity: new perspectives on an old problem. Int Dent J. 2002;52(Suppl 5):367-375.
[2] Pashley DH,Tay FR,Haywood VB,et al. Dentin Hypersensitivity: Consensus- Based Recommendations for the Diagnosis and Management of dentin hypersensitivity. Inside Dent. 2008;4:9 (Spec Iss):1-35.
[3] Drisko CH.Dentine hypersensitivity-dental hygiene and periodontal considerations.Int Dent J. 2002;52: 385-393.
[4] World Health Organization;WHO Expert Committee on CancerPain Relief and Active Supportive Care. Cancer pain relief and palliative care: ReportofaWHO ExpertCommittee[R]. World Health Organization technical report series;804. Geneva:World Health Organization, 1990: 1-75.
[5] Orchardson R,Gillam DG.Managing dentin hypersensitivity.J Am DentAssoc. 2006;137(7): 990-998.
[6] Carlsson AM. Assessment of chronic pain. I. Aspects of the reliability and validity of the visual analogue scale.Pain.1983; 16: 87-101.
[7] Pradeep AR,Sharma A.Comparison of clinical efficacy of a dentifrice containing calcium sodium phosphosilicate to a dentifrice containing potassium nitrate and to a placebo on dentinal hypersensitivity: a randomized clinical trial.J Periodontol. 2010;81(8): 1167-1173.
[8] Amarasena N,Spencer J,Ou Y,et al. Dentine hypersen¬sitivity in a private practice patient population in Australia.J Oral Rehabil.2011;38: 52-60.
[9] Que K,Ruan J,Fan X,et al.A multi-centre and cross-sectional study of dentine hypersensitivity in China.J Clin Periodontol. 2010;37: 631-637.
[10] Addy M.Etiology and clinical implications of dentine hypersensitivity.Dent Clin North Am.1990;34:503-514.
[11] Addy M. Dentine hypersensitivity: New perspectives on an old problem. Int Dent J. 2002;52(Suppl 5):367-375.
[12] Irwin CR,McCusker P. Prevalence of dentine hypersensitivity in a general dental population. J Irish Dent Assoc.1997;43: 7-9.
[13] Liu HC,Lan WH,Hsieh CC.Prevalence and distribution of cervical dentin hypersensitivity in a population in Taipei, Taiwan.J Endod.1998;24:45-47.
[14] Rees JS,Addy M.A cross-sectional study of dentine hypersensitivity. J Clin Periodontol.2002;29:997-1003.
[15] Al-Wahadni A,Linden GJ.Dentine hypersensitivity in Jordanian dental attenders: a case control study.J Clin Periodontol.2002;29:688-693.
[16] West NX. Dentine hypersensitivity. Monogr Oral Sci. 2006; 20:173-189.
[17] Amarasena N,Spencer J,Ou Y,et al.Dentine hypersensitivity— Australian dentists’perspective. Aust Dent J.2010;55:181-187.
[18] van Wijk AJ,Duyx MP,Hoogstraten J.The effect of written in¬formation on pain experience during periodontal probing.J ClinPe¬riodontol.2004;31: 282-285.
[19] Tammaro S,Wennström JL,Bergenholtz G.Root-dentin sensiti¬vity following non-surgical periodontal treatment.J Clin Periodon¬tol.2000;27: 690-697.
[20] von Troil B,Needleman I,Sanz M.A systematic review of the prevalence of root sensitivity following periodontal therapy.J Clin Periodontol.2002;29:173-177.
[21] Canakçi CF,Canakçi V.Pain experienced by patients undergoing different periodontal therapies. J Am Dent Assoc. 2007;138(12):1563-1573.
[22] Suge T,Kawasaki A,Ishikawa K,et al.Effects of plaque control on the patency of dentinal tubules: An in vivo study in beagle dogs. J Periodontol.2006;77(3):454-459.
[23] Markowitz K, Pashley DH. Discovering new treatments for sensitive teeth: The long path from biology to therapy.J Oral Rehabil.2008;35(4):300-315.
[24] Kawasaki A,Ishikawa K,Suge T,et al.Effects of plaque control on the patency and occlusion of dentine tubules in situ. J Oral Rehabil.2001;28(5):439-449.
[25] 吴亚菲,丁一,胡琳.牙颈部牙本质过敏症的激光脱敏治疗[J].华西口腔医学杂志,1995,13(4):261-263.
[26] Vaitkeviciene I,Paipaliene P,Zekonis G. Clinical effectiveness of dentin sealer in treating dental root sensitivi-ty following periodontal surgery. Medicina(Kaunas).2006;42(3):195-200.
[27] 樊明文.牙体牙髓病学[M].北京:人民卫生出版社, 2005:135-136.
[28] Isabel CCMP, Ana KMA, Marcos AJRM. Diagnosis and treat-ment of dentinal hypersensitivity.J Oral Sci.2009;51(3): 323-332.
[29] Saha S, Bateman GJ. Mucogingival grafting procedures－an up-date. Dent Update.2008;35(8): 561-562,565-568.
[30] Magalhaes AC. Chlorhexidine and green tea extract reduce dentin erosion and abrasion in situ.J Dent.2009;37 (12): 994-998.
[31] 张良,唐荣银,杨斌. 五倍子、黄芩提取物对牙龈卟啉菌超微结构的影响[J].牙体牙髓牙周病学杂志,2008,18(9) :515-517.
[32] 戴啊师,蔡春木,蓝海,等. 天然药物隔山消促进釉质再矿化的研究[J]. 牙体牙髓牙周病学杂志,2007,17(11) : 63.
[33] 祝旭. GLUMA 脱敏剂与复合树脂充填治疗重症牙本质过敏症的临床疗效观察[J]. 口腔医学,2010,30(2) : 96-97.
[34] Hajizadeh H,Akbari A,Ghavamnasiri M,et al. Clinical evaluation of a resin－based desensitizing agent and a self－etching adhesive on the reduction of postoperative sensitivity of amalgam restorations.J Contemp Dent Pract.2008;9(7): 9-16.
[35] Talesara K,Kulloli A,Shetty S,et al.Evaluation of potassium binoxalate gel and Nd:YAG laser in the management of dentinal hypersensitivity: a split-mouth clinical and ESEM study. Lasers Med Sci. 2012.[Epub ahead of print]
[36] 梁琪彬,邢思明,林成,等. 微波治疗牙本质过敏 98 例临床观察[J]. 牙体牙髓牙周病学杂志,2002,12(10) : 55.
[37] 徐文华,黄昊红,王凭. 紫外线治疗牙本质过敏症的临床观察[J].华西口腔医学杂志,2003,21(5): 413-414.
[38] 何钟勤,张志民,高心,等. 电凝治疗老年牙本质过敏症的电镜观察[J].中国老年学杂志,2002,7(22): 277-278.
[39] 梁自民,马梅,覃玉清,等. 冷冻治疗牙本质敏感的动物实验及 1853 个牙临床疗效分析[J].实用口腔医学杂志,2000,16(4): 291-293.
[40] Walsh LJ.Contemporary technologies for remineralization therapies: a review.Inter Dent Sa.2009:4(4):34-46.
[41] Orchardson R,Gangarosa LP Sr,Holland GR,et al. Dentine hypersensitivity into the 21st century. Arch Oral Biol.2009; 39(Supp1):113S-119S.
[42] Yoshiyama M,Noiri Y,Ozaki K,et al. Transmission electron microscopic characterization of hypersensitive human radiculardentin. J Dent Res.2008;69(9):1293-1297.
[43] Van Meerbeek B,De Munok J,Yoshida Y,et al. Adhesion to enamel and dentin:current status and future challenges.Oper Dent.2009;28(3):215-235.
[44] Layer TM. Development of a fluoridated,daily-use toothpaste containing NovaMin technology for the treatment of dentin hypersensitivity.J Clin Dent.2011;22(3):59-61.
[45] Burwell AK,Litkowski LJ,Greenspan DC.Calcium sodium phosphosilicate (NovaMin): remineralization potential.Adv Dent Res.2009;21(1):35-39.
[46] Gjorgievska E,Nicholson JW. Prevention of enamel demineralization after tooth bleaching by bioactive glass incorporated into toothpaste. Aust Dent J. 2011;56(2): 193-200.
[47] Wang Z,Sa Y,Sauro S,et al.Effect of desensitising toothpastes on dentinal tubule occlusion: a dentine permeability measurement and SEM in vitro study. J Dent. 2010;38(5): 400-410.
[48] 杜民权,台保军,江汉,等.含novamin生物活性材料的牙膏抗牙本质过敏症的临床试验[J].口腔医学研究,2004,12(6):641-643.
[49] 宋子元,谢咏梅,许乃同,等.四种治疗方法治疗牙本质敏感症的疗效比较[J].北京口腔医学,2012,20(4):222-224.
[50] Lepparanta O,Vaahtio M,Peltola T,et al. Antibacterial effect of bioactive glasses on clinically important anaerobic bacteria in vitro. J Mater Sci Mater Med.2008;19(2):547-551.
[51] 宋子元,谢咏梅,丁觉非,等.专业修复牙膏治疗牙本质敏感症临床疗效评价[J].中国实用口腔科杂志,2012,5(8):498-499.
[52] 龚逸明,丁小军,任颖.龈下刮治和根面平整术后牙本质过敏的临床评价[J].国际口腔医学,2009,36(3):256-259.
[53] Markowitz K. The original desensitizers: strontium and potassium salts. J Clin Dent.2009;20 (5):145-151.
[54] Orchardson R,Gillam DG.The efficacy of potassium saltsas agents for treating dentin hypersensitivity. J OrofacPain.2000; 14(1): 9- 19.