Pathological changes and clinical application standards of brain-death donor lung

doi:10.3969/j.issn.2095-4344.2013.18.008

Chinese Journal of Tissue Engineering Research ›› 2013, Vol. 17 ›› Issue (18): 3283-3286.doi: 10.3969/j.issn.2095-4344.2013.18.008

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Pathological changes and clinical application standards of brain-death donor lung

Nong Jiang¹, Sun Xu-yong¹, Qin Ke¹, Lai Yan-hua¹, Nie Feng¹, Dong Jian-huⁱ1, Wen Hai-tao¹, Li Zhuang-jiang¹, Ding Qi², Yang Jian-jun², He Chang-huan²

1 Research Institute of Transplantation Medicine, 303th Hospital of PLA, Nanning 530021, Guangxi Zhuang Autonomous Region, China
2 Department of Pathology, 303th Hospital of PLA, Nanning 530021, Guangxi Zhuang Autonomous Region, China

Received:2012-09-17 Revised:2013-03-21 Online:2013-04-30 Published:2013-04-30
Contact: Sun Xu-yong, Research Institute of Transplantation Medicine, 303th Hospital of PLA, Nanning 530021, Guangxi Zhuang Autonomous Region, China sxywn@sohu.com
About author:Nong Jiang, Research Institute of Transplantation Medicine, 303th Hospital of PLA, Nanning 530021, Guangxi Zhuang Autonomous Region, China 675542391@qq.com
Supported by:
Natural Science Foundation of Guangxi Science and Technology Bureau, No. Guikezi0991288

Abstract

Abstract:

BACKGROUND: Some scholars believe that many factors can lead to pathological changes of the lung in the process of brain-death
OBJECTIVE: To observe the pathological changes of brain-death donor lung, and to investigate the feasibility of its clinical transplantation.
METHODS: Twenty-three cases of brain-death donor lung received pathological biopsy, and hematoxylin-eosin staining, silver staining and PAS staining were used to observe the pathological changes of lung, and the microstructure of lung tissues was observed under electron microscope.
RESULTS AND CONCLUSION: Under the light microscope, bronchial and alveolar structure was complete, and edema, necrosis and defluxion could be observed in part of epithelial cells by hematoxylin-eosin staining, silver staining and PAS staining; alveolar interval was not widened obviously, but hyperemia was visible; small amount of bleeding and scattered lymphocytes could be seen around the vessels. Under the electron microscope, the slightly edema were observed in the brain-death alveolar cells, the cell nuclear chromatin condensed along the caryotheca, some nucleus appeared abnormity, mitochondria were engorgement, but no cell necrosis could be observed. Brain-death donor lung is suitable for clinical transplantation.

Key words: organ transplantation, basic experiment in organ transplantation, brain death, lung transplantation, donor, provincial grants-supported paper

CLC Number:

R318

Nong Jiang, Sun Xu-yong, Qin Ke, Lai Yan-hua, Nie Feng, Dong Jian-hui, Wen Hai-tao, Li Zhuang-jiang, Ding Qi, Yang Jian-jun, He Chang-huan. Pathological changes and clinical application standards of brain-death donor lung[J]. Chinese Journal of Tissue Engineering Research, 2013, 17(18): 3283-3286.

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References

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Pathological changes and clinical application standards of brain-death donor lung

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