Human umbilical cord mesenchymal stem cell transplantation combined with angioplasty for diabetic foot: 3 months angiographic evaluation

doi:10.3969/j.issn.2095-4344.2013.14.011

Abstract

Abstract:

BACKGROUND: At present, there is no effective drug for the treatment of diabetic arteniosclerosis obliterons, and most of the patients have to receive amputation, and have poor prognosis.
OBJECTIVE: To treat the diabetic foot with human umbilical cord mesenchymal stem cells transplantation combined with angioplasty, and to perform the angiographic evaluation at 3 months after operation.
METHODS: Forty cases (52 limbs) diagnosed with severe symptoms of Fontain Ⅳ diabetic foot accompanied with varying degrees of lower extremity arterial disease were included. The 12 cases (18 limbs) in the control group received simple interventional treatment, and 28 cases (34 limbs) in the experimental group were given human umbilical cord mesenchymal stem cells endovascular infusion and injection around the ulcer. Then all the patients were followed-up for 3 months.
RESULTS AND CONCLUSION: Local cool-feeling, pain and numbness after treatment were improved continuously in a certain extent; skin temperature, ankle-brachial pressure index and claudication distance were improved persistently. Re-examination angiography at 3 months after treatment showed that the neovessels were increased significantly and the ulcer was healed or decreased gradually. No serious complications and adverse reactions were observed before and after infusion. The results indicate that human umbilical cord mesenchymal stem cell transplantation combined with angioplasty is a safe, effective and satisfactory method for severe diabetic foot.

Key words: stem cells, stem cell transplantation, type 2 diabetes, peripheral vascular disease, diabetic foot, ulcer, intervention, angioplasty, human umbilical cord mesenchymal stem cells, transplantation, efficacy, complications, provincial grants-supported paper, stem cell photographs-containing paper

CLC Number:

R394.2

Qin Han-lin, He Ke-wu, Gao Bin, Ji Ya-li, Huang Yong-cui, Wang Sheng-qin, Hu Guo-ping, Zhou Xue-yong. Human umbilical cord mesenchymal stem cell transplantation combined with angioplasty for diabetic foot: 3 months angiographic evaluation[J]. Chinese Journal of Tissue Engineering Research, 2013, 17(14): 2544-2551.

Figures/Tables 4

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