Alendronate and raloxifene affect alveolar bone resorption

doi:10.3969/j.issn.2095-4344.2013.07.002

Abstract

Abstract:

BACKGROUND: Studies have shown that alendronate and raloxifene can suppress osteoporosis.
OBJECTIVE: To evaluate the anti-osteoporosis effect of alendronate and raloxifene in rat models of osteoporosis and alveolar bone resorption.
METHODS: Totally 56 female Sprague-Dawley rats were enrolled to establish animal models of osteoporosis and alveolar bone resorption. Ovariectomized+ligation group and ligation group were respectively divided into three subgroups: alendronate, raloxifene and non-drug groups. Ovariectomized group and sham operation group (blank control) were set. Intragastric administration was performed at 5 days after modeling, once a day, totally for 3 months. Blood biochemical markers, bone mineral density measurement and histomorphological method were done for evaluation of drug effectiveness.
RESULTS AND CONCLUSION: As compared with the raloxifene groups, alendronate groups could significantly reduce alkaline phosphatase and serum calcium levels and promote bone mineral density in the ovariectomized rats. It is confirmed that both alendronate and raloxifene can reduce bone loss to prevent osteoporosis and alveolar bone resorption, but alendronate is a better one.

Key words: tissue construction, oral tissue construction, alendroinate, raloxifene, bone mineral density, osteoporosis, alveolar bone resorption, provincial grants-supported paper

CLC Number:

R318

Chen Jin-bo, Liu Tie-yu, Yan Mei-feng, Qu Xiao-juan. Alendronate and raloxifene affect alveolar bone resorption[J]. Chinese Journal of Tissue Engineering Research, 2013, 17(7): 1146-1150.

Figures/Tables 3

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