Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (27): 5092-5096.doi: 10.3969/j.issn.2095-4344.2012.27.029

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Immune function detection of umbilical cord blood from newborns of different genders between cesarean section and vaginal birth

Liu Ke-qin1, Liu Chen2, Yin Wei-dong3, Zhang Bin1   

  1. 1The First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, Hebei Province, China;
    2The Armed Police Corps Hospital in Beijing, Beijing 100027, China;
    3Hebei North University, Zhangjiakou 075000, Hebei Province, China
  • Received:2012-01-11 Revised:2012-01-22 Online:2012-07-01 Published:2013-11-01
  • Contact: Yin Wei-dong, Master, Professor, Hebei North University, Zhangjiakou 075000, Hebei Province, China yinweidong1531@sina.com
  • About author:Liu Ke-qin, Associate chief technician, the First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, Hebei Province, China yinweidong1531@sina.com

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Abstract:

BACKGROUND: There have been many factors that influence neonatal immune function. In vaginal birth, uterine contraction makes the newborn child in a relative ischemic hypoxic status, and the type of delivery can influence the immune status of the newborn children. The newborn children delivered by cesarean section have low immunity and predispose to secondary infection.
OBJECTIVE: To explore the influence of cesarean section versus vaginal birth on immune function of umbilical cord blood of newborn children of different genders.
METHODS: 100 cases of women who had full-term single birth were selected, including 50 cases subjected to vaginal delivery (30 male babies and 20 female babies) and 50 cases subjected to cesarean section (30 male babies and 20 female babies). Umbilical cord blood immunoglobulin (IgG, IgA, IgM), the complement (C3, C4), C-reactive protein of newborn children were detected by transmission immune turbidity method using automatic biochemical analyzer. T lymphocyte antigen (CD4, CD8) was determined by flow cytometry.
RESULTS AND CONCLUSION: In the cesarean section group, the level of umbilical cord blood lymphocyte CD4 antigen and the mixed antigen CD4 and CD8 in female babies was significantly higher (P < 0.01), but CD8 antigen level was significantly lower (P < 0.01), than in the vaginal birth group. In the cesarean section group, umbilical cord IgA and IgM level in female babies was significantly higher (P < 0.01), but IgG level was significantly lower (P < 0.05) than in male babies. Umbilical cord IgG, IgM, C-reactive protein levels of female babies in the cesarean section group were significantly lower than in the vaginal birth group (P < 0.01). In the cesarean section group, umbilical cord IgM level of male babies was significantly lower (P < 0.01), but C-reactive protein level of male babies was significantly higher (P < 0.01), than in the vaginal birth group (P < 0.01). These findings suggest that the type of delivery produces different influences on immune function of newborn children of different genders, and cesarean section can decrease the immune function of newborn children.

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