Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (27): 5067-5071.doi: 10.3969/j.issn.2095-4344.2012.27.024

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Survival of human adipose-derived mesenchymal stem cells transplanted via the tail vein in rat brain with cerebral ischemia

Gao Xu, Dong Tao, Li Zhi-qing, Jiang Wei, Wei Xue-zhong, Cao Peng, Liang Guo-biao   

  1. Department of Neurosurgery, the General Hospital of Shenyang Military Command Area of Chinese PLA, Shenyang 110840, Liaoning Province, China
  • Received:2011-11-27 Revised:2011-12-15 Online:2012-07-01 Published:2013-11-01
  • Contact: Liang Guo-biao, Chief physician, Department of Neurosurgery, the General Hospital of Shenyang Military Command Area of Chinese PLA, Shenyang 110840, Liaoning Province, China liangguobiao6708@163.com
  • About author:Gao Xu☆, Studying for doctorate, Attending physician, Department of Neurosurgery, the General Hospital of Shenyang Military Command Area of Chinese PLA, Shenyang 110840, Liaoning Province, China gaoelmer@hotmail.com

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Abstract:

BACKGROUND: Mesenchymal stem cells transplantation can improve the neurological function of ischemic cerebrovascular disease.
OBJECTIVE: To explore the effect of human adipose-derived mesenchymal stem cells transplanted via the tail vein on functional recovery in rats with focal cerebral ischemia.
METHODS: Focal cerebral ischemia rat models were established, and then rat models were divided into experimental group and control group. In the experimental group, 5×106 adipose-derived mesenchymal stem cells were injected into rat models via the tail vein, and the rat models in the control group were treated without cell transplantation.
RESULTS AND CONCLUSION: Behavioral score of neurological defects in two groups was gradually reduced with the time prolonged after cell transplantation. At 14 and 21 days after transplantation, the behavioral score of rats in the experimental group was significantly lower than that in the control group (P < 0.05) and the improvement of experimental group was significantly better than that of the control group (P < 0.01); transplanted adipose-derived mesenchymal stem cells were gathered and survived surrounding the blood vesselss and periischemic areas in rats with focal cerebral ischemia. Adipose-derived mesenchymal stem cells transplanted via the tail vein can survive in the host brain and improve neurological function.

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