Features of animal models of osteonecrosis of the femoral head

doi:10.3969/j.issn.2095-4344.2000

Abstract

Abstract:

BACKGROUND: The pathogenesis of femoral head necrosis has not been completely clarified. Due to the lack of experimental animal models that can reliably simulate the various stages of human femoral head necrosis, research in the prevention and treatment of osteonecrosis of the femoral head is hindered.
OBJECTIVE: To summarize the construction methods of animal models of osteonecrosis of the femoral head, advantages and disadvantages of animal models, so as to provide basis and direction for the model improvement.
METHODS: Keywords of “femoral head necrosis, animal model or osteonecrosis of femoral head, animal model” were used to search the databases of CNKI and PubMed. The articles related to establishing the animal models of osteonecrosis of the femoral head published between January 2000 and April 2019 were retrieved.
RESULTS AND CONCLUSION: Fifty-one articles eligible for inclusion criteria were included. There are few studies on the establishment of the animal models of osteonecrosis of the femoral head, which mainly simulate the early pathological features of the disease, and unable to progress to the end stage of necrotic mechanical collapse. As the ideal animal model of femoral head necrosis is not yet to be found, the efficacy of new treatments cannot be evaluated, the animal model of femoral head necrosis remains to be a challenging that needs to be improved.

Key words: osteonecrosis of the femoral head, animal models, tetrapods, biped, model features, construction methods, research progress, ideal model

CLC Number:

Ge Yingjie1, Cai Miaoxin1, Li Linpeng1, Chen Haoyan1, Pang Zhihui2, Fan Yueguang3. Features of animal models of osteonecrosis of the femoral head[J]. Chinese Journal of Tissue Engineering Research, 2019, 23(35): 5690-5696.

Figures/Tables 1

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