Chinese Journal of Tissue Engineering Research ›› 2019, Vol. 23 ›› Issue (25): 4068-4074.doi: 10.3969/j.issn.2095-4344.1790

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Application potential of different origin stem cells in oral bone regeneration

Shen Mengjie, Yang Kun, Liu Qi
  

  1. Department of Periodontology, Stomatological Hospital Affiliated to Zunyi Medical University, Zunyi 563003, Guizhou Province, China
  • Revised:2019-04-28 Online:2019-09-08 Published:2019-09-08
  • Contact: Liu Qi, MD, Professor, Department of Periodontology, Stomatological Hospital Affiliated to Zunyi Medical University, Zunyi 563003, Guizhou Province, China
  • About author:Shen Mengjie, Master candidate, Department of Periodontology, Stomatological Hospital Affiliated to Zunyi Medical University, Zunyi 563003, Guizhou Province, China
  • Supported by:

    the National Natural Science Foundation of China, No. 81860196 (to LQ) and 81760199 (to YK)

Abstract:

BACKGROUND: In recent years, with the development of stem cell and regeneration technologies, bone tissue engineering has been rapidly developed. Despite there are a variety of seed cells for bone tissue engineering, researchers need to decide which types of stem cells are the best suitable for their specific purposes. To date, there is no ideal treatment for oral bone tissue repair, although a plenty of therapeutic methods have been proposed. Therefore, it will provide a new idea for repairing oral bone defects by fully utilizing the potential of stem cells during bone regeneration.
OBJECTIVE: To review the osteogenic potential of stem cells from different sources on oral bone regeneration, thereby providing a basis for selecting seed cells for tissue engineering.
METHODS: Databases of CBM, CNKI, PubMed, Elsevier, and Web of Science were retrieved with the keywords of “stem cell, bone repair, alveolar bone regenerate, osteogenesis, bone tissue” in English and Chinese, respectively. After initial screening of titles and abstracts, irrelevant articles were excluded and 81 eligible articles were included in final analysis.
RESULTS AND CONCLUSION: Tissue engineering technology provides a new approach to oral bone regeneration, but the choice of stem cells has not been standardized. Many types of stem cells have been used for bone tissue regeneration, but their roles in the body vary due to different origins of stem cells. Therefore, choosing a suitable type of stem cells is important for the repair of specific tissue damage. In this review, we compared the advantages and disadvantages of embryonic stem cells, mesenchymal stem cells and induced pluripotent stem cells in the oral bone regeneration, and attempted to provide a reference for the selection of seed cells for the regeneration and repair of oral bone tissue.

Key words: stem cells, embryonic stem cells, mesenchymal stem cells, induced pluripotent stem cells, alveolar bone repair, bone regeneration, osteogenesis, bone tissue, National Natural Science Foundation of China

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