Chinese Journal of Tissue Engineering Research ›› 2019, Vol. 23 ›› Issue (10): 1599-1604.doi: 10.3969/j.issn.2095-4344.1575

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Fluid structure interaction analysis of transcatheter aortic valve implantation

Zhu Hongwei, Yuan Quan, Liu Xingming, Cong Hua   

  1. National Demonstration Center for Experimental Mechanical Engineering Education of Shandong University, Key Laboratory of High-Efficiency and Clean Mechanical Manufacture of Ministry of Education, Jinan 250061, Shandong Province, China
  • Contact: Yuan Quan, Professor, Master’s supervisor, National Demonstration Center for Experimental Mechanical Engineering Education of Shandong University, Key Laboratory of High-Efficiency and Clean Mechanical Manufacture of Ministry of Education, Jinan 250061, Shandong Province, China
  • About author:Zhu Hongwei, Master candidate, National Demonstration Center for Experimental Mechanical Engineering Education of Shandong University, Key Laboratory of High-Efficiency and Clean Mechanical Manufacture of Ministry of Education, Jinan 250061, Shandong Province, China
  • Supported by:

    the National Natural Science Foundation of China, No. 31170906 (to YQ)

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Abstract:

BACKGROUND: Cardiac valve replacement provides an effective therapeutic means for valvular heart disease. Compared with thoracotomy surgery, interventional treatment, typified by transcatheter aortic valve implantation, has the advantages of minor trauma and rapid recovery. At present, the transcatheter aortic valve replacement is rarely applied in clinical practice. Existing studies mainly focus on the changes of physiological conditions after surgery, while little is reported on the transcatheter aortic valve models.

OBJECTIVE: To explore the deformation and stress distribution features of the transcatheter aortic valve, and to verify its working performance.
METHODS: The finite element geometric model and mathematical model of the aortic valve, including the aortic valve, blood vessel wall, blood and stent, were established. The fluid structure interaction analysis was carried out by the immersion boundary method, and the effective orifice area index was calculated to verify the performance of the model.

RESULTS AND CONCLUSION: During the course of blood shock, the valve leaflets were curl, and the maximum deformation occurred at 1/4 and 3/4 of the valve leaflet free edge. The largest equivalent stress of the aortic valve model was on the stent, but it is almost unformed. The stress concentration of the valve leaflets was located at the curved site of the free edge and the suture points of the leaflets and stents, where a damage easily occurred. The dynamic flow experiments show that the process of the simulation model deformation and effective orifice area index are close to the experimental results. Therefore, the simulation model is reasonable and effective.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Aortic Valve, Heart Valve Diseases, Tissue Engineering

CLC Number: