Distribution characteristics of polymorphism of human leukocyte antigen C of hepatitis B virus carriers in patients from Shenzhen

doi:10.3969/j.issn.2095-4344.0586

Abstract

Abstract:

BACKGROUND: Due to the development of human leukocyte antigen (HLA) typing techniques, there are a large number of studies reporting the relationship between hepatitis B virus (HBV) and HLA-A, -B, and -DR, but little is reported on the relationship between HBV and HLA-C.
OBJECTIVE: To analyze the polymorphism of HLA-C of HBV carriers in Shenzhen.
METHODS: PCR-based typing method was used to analyze the polymorphism of HLA-C locus alleles of 122 HBV carriers and 186 healthy volunteers (control group) in Shenzhen.
RESULTS AND CONCLUSION: Twenty-four alleles for the locus HLA-C were detected in the control group, of which HLA-C *01:02, 07:02, 03:04 and 08:01 were the most common. In the HBV carrier group, 18 kinds of HLA-C alleles were detected, including the common alleles HLA-C*07:02, 01:02, 03:04, 08:01. HLA-C*12:02 was not detected in the HBV carries group. The detection rate of HLA-C*12:02 in the control group was significantly higher than that in the HBV carrier group. These results imply that the frequency distribution of HLA-C alleles of HBV carriers in Shenzhen also have a high degree of genetic polymorphism compared with the control group. There may be association between HBV carriers and HLA-C*12:02 alleles. HLA-C*12:02 allele possibly plays a negative role in HBV carriers in Shenzhen.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Human Leukocyte Antigen, Alleles, Tissue Engineering

CLC Number:

R446

Quan Zhanrou, He Liumei, Chen Hao, Hong Wenxu, Gao Suqing . Distribution characteristics of polymorphism of human leukocyte antigen C of hepatitis B virus carriers in patients from Shenzhen[J]. Chinese Journal of Tissue Engineering Research, 2019, 23(3): 482-486.

Figures/Tables 3

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