The safety and efficacy of bone marrow stem cell transplantation for ischemic heart failure: a Meta-analysis

doi:10.3969/j.issn.2095-4344.0421

Abstract

Abstract:

BACKGROUND: The bone marrow stem cells (BMSCs) transplantation has been used for the treatment of ischemic heart failure in clinic. But the efficacy and safety of BMSCs transplantation remains controversial.
OBJECTIVE: To systematically assess the efficacy and safety of BMSCs transplantation on ischemic heart failure through a Meta-analysis.
METHODS: PubMed, Cochrane Library (Issue 10, 2016), Embase, CNKI, CBM, VIP, WanFang were search for relevant randomized controlled trials (RCTs). After data extracting and quality assessing, Meta-analysis was performed using RevMan5.3 software.
RESULTS AND CONCLUSION: A total of 8 RCTs involving 350 patients, 191 in the BMSCs group and 159 in the conventional therapy group, were included. Meta-analysis results showed that: compared with the conventional therapy, BMSCs transplantation could increase the left ventricular ejection fraction [MD=4.68, 95% CI (1.79, 7.56), P < 0.01]. But there was no significant difference in decreasing left ventricular end-diastolic volume [MD=-3.86, 95% CI (-9.90, 2.17), P=0.21] and left ventricular end-systolic volume [MD=-3.20, 95% CI (-9.21, 2.80), P=0.30]. And the incidence of adverse events was not significantly different [RR=0.85, 95% CI (0.25, 2.89), P=0.79] in the course of the treatment. Overall findings indicate that BMSCs transplantation for ischemic heart failure is safe and able to significantly increase patient’s left ventricular ejection fraction. However, BMSCs transplantation by intracoronary injection may have no effect on the left ventricular remodeling in ischemic heart failure patients. Due to the limitations of current studies, high-quality RCTs are needed to further verify our findings.

中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

Key words: Bone Marrow, Stem Cell Transplantation, Heart Failure, Meta-Analysis, Tissue Engineering

CLC Number:

R349.2

Wu Ni-na, He Jian-yun, Zhu Lei, Li Xiao-mei. The safety and efficacy of bone marrow stem cell transplantation for ischemic heart failure: a Meta-analysis[J]. Chinese Journal of Tissue Engineering Research, 2018, 22(1): 119-125.

Figures/Tables 3

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