“Accordion” technology treats nonunion in model rabbits

doi:10.3969/j.issn.2095-4344.0384

Abstract

Abstract:

BACKGROUND: “Accordion” technique achieves satisfactory outcomes in the treatment of nonunion, but there is a lack of basic research.
OBJECTIVE: To verify that the “accordion” technique is effective for nonunion in New Zealand white rabbits.
METHODS: The model of unilateral femoral fracture with noninfectious nonunion was created in the New Zealand white rabbits. The model rabbits were then divided into three groups: experimental group: treated with “accordion” technique (4 weeks of pressure with external fixator at a speed of 0.5 mm/d, then 2 weeks of retraction at the same speed, and finally 4 weeks of pressure); control group: external fixation and pressure; blank control group: only external fixation. The rabbits underwent X-ray examination at 2, 4, 6, 8 and 12 weeks. The fracture specimens were taken for hematoxylin-eosin staining and histological observation.
RESULTS AND CONCLUSION: The X-ray examination of the experimental group suggested that the fracture
was healed, while the control group and the blank control group still did not heal (P < 0.01). Histological examination showed that the fracture stump of the experimental group changed from the nonunion state to the healing state, and the blank control and control groups showed no obvious changes. Thus, “accordion” technology is a simple, minimally invasive and efficient treatment method for nonunion.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Models, Animal, External Fixators, Femur, Tissue Engineering

CLC Number:

R318

Feng Zhen1, Zhang Meng2, Wu Wei-na3. “Accordion” technology treats nonunion in model rabbits[J]. Chinese Journal of Tissue Engineering Research, 2018, 22(32): 5175-5179.

Figures/Tables 2

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