Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (14): 2517-2520.doi: 10.3969/j.issn.1673-8225.2011.14.011

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Effects of prostaglandin E1 on in vitro proliferation of human adipose derived stromal cells 

Yang Huan-na1, Cui Zheng-jun1, Seung-Kyu Han2, Hyup-Woo Lee2, Zou Shi-bo1, Han Zhao-feng1, Zhou Jian1   

  1. 1First Affiliated Hospital of Zhengzhou University, Zhengzhou  450002, Henan Province, China
    2Korea University Medical Center Guro Hospital, 152-703
  • Received:2011-01-19 Revised:2011-03-02 Online:2011-04-02 Published:2013-11-02
  • Contact: Cui Zheng-jun, Professor, Chief physician, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450002, Henan Province, China
  • About author:Yang Huan-na★, Master, Physician, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450002, Henan Province, China yanghn05@163.com

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Abstract:

BACKGROUND: Recently, research and application of human adipose derived stromal cells (ADSCs) has become a hotspot; however, there are few reports addressing prostaglandin E1 (PGE1) effects on ADSCs proliferation.
OBJECTIVE: To explore the effects of PGE1 on ADSCs proliferation.
METHODS: ADSCs were obtained from human normal adipose tissue after isolation and culture. The cultured ADSCs were treated with five different concentration of PGE1, which were 3×10-6, 6×10-6, 9×10-6, 12×10-6 mol/L, and 0×10-6 mol/L (control group). After 3 days, the cell morphology and proliferation were observed.
RESULTS AND CONCLUSION: There was no obervious different among the experimental groups. And the cell number of each experimental group was obervious elevated, compared with that of the control group (P < 0.05). These findings indicated that ① PGE1 promoted the proliferation of ADSC; ② The effect of PGE1 had no dose dependent.

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