Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (45): 8491-8494.doi: 10.3969/j.issn.1673-8225.2010.45.031

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Research progress in the relationship between cell immortalization and carcinogenesis

Wu Di1, Jia Yong-feng1, Wu Yan2   

  1. 1 Pathology Center, 2 Department of Histology and Embryology, Inner Mongolia Medical College, Huhhot  010059, Inner Mongolia Autonomous Region, China
  • Online:2010-11-05 Published:2010-11-05
  • Contact: Jia Yong-feng, Doctor, Professor, Pathology Center, Inner Mongolia Medical College, Huhhot 010059, Inner Mongolia Autonomous Region, China yfjia1973@yahoo.com.cn
  • About author:Wu Di★, Studying for master’s degree, Pathology Center, Inner Mongolia Medical College, Huhhot 010059, Inner Mongolia Autonomous Region, China wudi080101@126.com
  • Supported by:

    the “Spring Sunshine” Project of Education Ministry, No. Z2007-1-01002*; the Stem Cell Application Technique Innovation Team Foundation, the Application Technique Research and Development Fund Project of Inner Mongolia Autonomous Region, No. 2009*

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Abstract:

BACKGROUND: Many differences and connections have been observed between immortalized cells and tumor cells in the level of gene, protein and phenotypic types. It was some different opinions that exist in the relationship between the two cell types.
OBJECTIVE: To analyze the correlation between immortalized cells and tumor cells, and to summarize research progress and perspective of studying tumor cell production.
METHODS: Pubmed and SpringerLink databases were searched by computer for articles published from January 2001 to January 2010. The key words were “cellular immortality, cancer mechanism”. China National Knowledge Infrastructure database was searched by computer for articles published from January 2001 to January 2010. The key words were “cellular immortality, cancer mechanism”.
RESULTS AND CONCLUSION: A total of 95 relevant articles were collected including 35 Chinese articles and 60 English articles. Finally, 41 articles were used after the earlier publishers and similar repeated studies were excluded. Immortalized cells are not tumor cells. It is generally believe that cells immortalized passages is a necessary step in the process of malignant transformation of cells, if just as it said so, the culture of tumor cells should be easy. In fact, in vitro culture of tumor cells is very difficult; some scholars have questioned the relationships between the two. At present, the theory on the arising of tumor cells exists as follows: aneuploidy hypothesis, DNA immortalized chain hypothesis, cancer stem cell hypothesis and so on. The further study of the relationships between the two is helpful to the application of immortalized cells and beneficial to tumor treatment.

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