Abstract:

BACKGROUND: Numerous animal studies have shown that the brain of mature animals contains regeneration field of neural cells. New neural cells produced by hippocampal dentate gyrus can migrate to the granular layer, and differentiate into functional neural cells.
OBJECTIVE: To provide new ideas for the treatment of brain injury by studying the feature of neural stem cells and the affected factors of the new cells differentiation, migration and survival.
METHODS: The computer was applied to retrieve the articles in CNKI periodical full-text database and PubMed database published from 1996 to 2009. Words for retrieve were “Neural stem cells, PSA-NCAM, cerebral infarction”. Articles concerning PSA-NCAM and neurogenesis in the rat hippocampus were included. The literature of irrelevant purpose and repetitive content was excluded, and then 48 literatures were retained to summarize.
RESULTS AND CONCLUSION: Neurogenesis continues in the hippocampal dentate gyrus, the subventricular zone of the lateral ventricle and olfactory bulb. These regions contain abundant neural stem cells, which have the ability of proliferation, differentiation and regeneration. The central nerve has many cytokines that can promote proliferation, differentiation and migration of neural stem cells, including PSA-NCAM.