Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (40): 7443-7446.doi: 10.3969/j.issn.1673-8225.2010.40.008

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Cell transplantation for the treatment of advanced-stage spinal cord injury: A Meta analysis

Deng Zhou-ming, Cai Lin, Zhang Yi, Liu Zheng-jie, Chen Zhi-long, Yang Biao   

  1. Department of Orthopedics, Zhongnan Hospital, Wuhan University, Wuhan  430071, Hubei Province, China
  • Online:2010-10-01 Published:2010-10-01
  • Contact: Cai Lin, Professor, Doctoral supervisor, Department of Orthopedics, Zhongnan Hospital, Wuhan University, Wuhan 430071, Hubei Province, China guke3224@yahoo.com.cn
  • About author:Deng Zhou-ming★, Studying for master’s degree, Department of Orthopedics, Zhongnan Hospital, Wuhan University, Wuhan 430071, Hubei Province, China dzm2008m@163.com

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Abstract:

BACKGROUND: Neural regeneration and functional recovery following spinal cord injury (SCI) is still a hot focus and difficulty in the medical circle. Recently, cell transplantation as a new therapeutic method with deep research has obtained study outcomes, but its clinical curative effect remains controversial.
OBJECTIVE: To evaluate the effectiveness of cell transplantation for the treatment of advanced-stage SCI by meta-analyses. 
METHODS: Cochrane Database (Issue 4, 2010), PubMed (1966-2010), EMbase (1989-2010), Chinese Biomedical Literature Database (1978-2010), Wanfang Database (1982-2010) were searched to identify the literatures. All studies about cell transplantation for the treatment of advanced-stage SCI were adopted; the quality of researches was critically appraised and data were extracted by 2 investigators independently. It was collected that the patients’ American Spinal Injury Association scores of pre-operation and post-operation, including motor score, light touch and pinprick.
RESULTS AND CONCLUSION: Seven cohort studies involving 388 patients were collected. The results of Meta-analyses showed that the difference of American Spinal Injury Association scores between pre-operation and post-operation had statistical significance (P < 0.000 01). The mean increase in ASIA motor scores was 6.14 [95%CI (3.43, 8.85), P < 0.000 01], and the mean increase for light touch was 8.63 [95%CI (5.61, 11.66), P < 0.000 01] and the mean increase for pinprick was 10.65 [95%CI (7.58, 13.72), P < 0.000 01]. There were no severely adverse effects after cell transplantation. Cell transplantation could be a treatment method for advanced-stage SCI, but the effectiveness and safety required being proved by the randomized controlled trials of large sample.

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