Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (19): 3569-3572.doi: 10.3969/j.issn.1673-8225.2010.19.031

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Endothelial progenitor cells and ischemic stroke

Li Huan-huan1, He Xu2, Liu Kang-ding1   

  1. 1Department of Neurology, First Hospital, Jilin University, Changchun   130021, Jilin Province, China;
    2Department of Pathology, Key Laboratory of Pathobiology of Ministry of Education, Norman Bathune College of Medicine, Jilin University, Changchun  130021, Jilin Province, China
  • Online:2010-05-07 Published:2010-05-07
  • Contact: Liu Kang-ding, Doctoral supervisor, Chief physician, Department of Neurology, First Hospital, Jilin University, Changchun 130021, Jilin Province, China kangdingliu@163.com
  • About author:Li Huan-huan, Studying for master’s degree, Physician, Department of Neurology, First Hospital, Jilin University, Changchun 130021, Jilin Province, China huanhuan19840620＠163.com
  • Supported by:

    the National Natural Science Foundation of China, No. 30770755*

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Abstract:

BACKGROUND: Endothelial progenitor cells not only predict the degree of vascular injury in early stage, but also repair damaged endothelial cells, promote lumen structure formation of new vessels and participate in neural regeneration. Endothelial cell transplantation has been widely applied in treatment of vessel-related diseases.
OBJECTIVE: To summarize biological characteristics and latest research advancement of endothelial progenitor cells in the field of cerebral ischemic stroke, so as to provide theoretical support for its clinical application.
METHODS: We retrieved Medline and HighWire Press databases with the key words of “endothelial progenitor cells, ischemic infarction” for articles published from January 2000 to December 2009. Inclusion criteria: research closely related to angiogenesis, endothelium and neural regeneration. Exclusion criteria: obsolete, repetitive articles and those lack of credibility.
RESULTS AND CONCLUSION: Totally 126 literatures were screened out by computer, according to inclusion and exclusion criteria, 28 documents of which were involved in the analysis. Endothelial progenitor cells can repair damaged endothelium, attenuate the development of atherosclerosis and promote new vessels formation in ischemic tissue. Endothelial progenitor cells participate in angiogenesis after ischemic stroke, fight against stent thrombosis and restenosis, predict the development and prognosis of cerebral ischemia, and have a wide range of application prospects in the treatment of cerebral ischemic stroke.

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