Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (19): 3565-3568.doi: 10.3969/j.issn.1673-8225.2010.19.030

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Relationship of mesenchymal stem cells with tumor growth and development

Liu Han1, Chen Jun2, Xu Zhi-shun2   

  1. 1Five-Year-Course Class Three, Grade 2006 Clinical Medicine Department, Medical College, Shandong University, Jinan  250012, Shandong Province, China;
    2Department of Urinary Surgery, Qilu Hospital, Shandong University, Jinan  250012, Shandong Province, China
  • Online:2010-05-07 Published:2010-05-07
  • About author:Liu Han, Five-Year-Course Class Three, Grade 2006 Clinical Medicine Department, Medical College, Shandong University, Jinan 250012, Shandong Province, China

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Abstract:

BACKGROUND: Mesenchymal stem cells are the cells with the potential of multiple-directional differentiation. Tumor can induce migration of mesenchymal stem cells into tumor tissue. There are many studies concerning the influence of mesechymal stem cells on tumor growth and development.
OBJECTIVE: To review the influence of mesechymal stem cells on tumor growth and development.
METHODS: The PubMed database(http://www.ncbi.nlm.nih.gov/PubMed) (2000-01/2009-06) was searched online. The key words were “mesenchymal stem cell, myofibroblast, neoplasms”. The language was limited as English. Totally 8 372 papers were included. Finally, 37 articles were accorded with inclusion criteria.
RESULTS AND CONCLUSION: Mesenchymal stem cells can migrate into tumor tissue and accelerate tumor development under the induction of tumor tissue, which may be related to the influence of mesenchymal stem cells on tumor stroma remodeling, local immune status and vascular formation. However, some studies have suggested that mesenchymal stem cells suppress tumor growth. Therefore, further studies addressing the relationship between mesenchymal stem cells and tumor development are necessary, which may strengthen our recognition to the mechanism of tumor development.

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