Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (1): 166-170.doi: 10.3969/j.issn.1673-8225.2010.01.035

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Role of adipose-derived mesenchymal stem cells in bone tissue engineering

Jia Jing-han, Zhang Zhi, Wang Xiang-peng, Zou Dong-qing   

  1. Department of Orthopaedics, Affiliated Ruikang Hospital of Guangxi Traditional Chinese Medical University, Nanning  530011, Guangxi Zhuang Autonomous Region, China
  • Online:2010-01-04 Published:2010-01-04
  • Contact: Zhang Zhi, Department of Orthopaedics, Affiliated Ruikang Hospital of Guangxi Traditional Chinese Medical University, Nanning 530011, Guangxi Zhuang Autonomous Region, China zhangzhiym@qq.com
  • About author:ia Jing-han, Chief physician, Department of Orthopaedics, Affiliated Ruikang Hospital of Guangxi Traditional Chinese Medical University, Nanning 530011, Guangxi Zhuang Autonomous Region, China jia_jing_han@yahoo.com.cn

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Abstract:

BACKGROUND: At present, bone defects usually repaired by autologous bone, allogenic bone, synthetic bone substitutes and other methods, which received poor clinical results. Preliminary studies have shown that adipose-derived mesenchymal stem cells (ADSCs) possess strong proliferation ability and differentiation potential, and can be induced differentiate into bone.

OBJECTIVE: To analyze the application of ADSCs in bone tissue engineering, and to identify whether ADSCs can be used as seed cells in bone tissue engineering.

METHODS: The databases of PubMed (1999-01/2008-12) and Tongfang (2003-01/2008-12) was retrieved using key words of “adipose tissue-derived mesenchymal stem cells, adipose mesenchymal stem cells, adipose stem cell; osteogenic induction, osteogenic inducement, bone induction, osteoblastic induced; chondroblast induction, cartilage induction; bone tissue engineering, tissue engineering bone, tissue engineering of bone”.

RESULTS AND CONCLUSION: A total of 361 literatures were collected, including 246 in Chinese and 115 in English. Totally 29 literatures were accordant with the study criteria. ADSCs is a truly multi-directional differentiation potential cells, which possess strong amplification and self-renewal potential, and can be directional differentiated into osteoblasts, cartilage cells, bone cells and muscle cells. It can be used as seed cells in bone tissue engineering when matching appropriate stents.

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