Chinese Journal of Tissue Engineering Research ›› 2026, Vol. 30 ›› Issue (12): 3075-3082.doi: 10.12307/2026.664
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Ma Shanxin1, Zheng Jianling2, Cheng Jian1, Lin Xi1, Li Qiuyuan1, Wang Li1, Zeng Yangkang1, Song Luping3
Received:
2025-04-02
Accepted:
2025-08-06
Online:
2026-04-28
Published:
2025-09-30
Contact:
Song Luping, PhD, Chief physician, Department of Rehabilitation Medicine, Shenzhen Nanshan People’s Hospital, Shenzhen 518300, Guangdong Province, China
About author:
Zheng Jianling, Department of Physical Therapy, Beijing Bo’ai Hospital, China Rehabilitation Research Center, Beijing 100068, China
Ma Shanxin and Zheng Jianling contributed equally to this work.
Supported by:
CLC Number:
Ma Shanxin, Zheng Jianling, Cheng Jian, Lin Xi, Li Qiuyuan, Wang Li, Zeng Yangkang, Song Luping. Early intelligent active assistance in walking for hemiplegic patients under suspension protection: #br# a randomized controlled trial[J]. Chinese Journal of Tissue Engineering Research, 2026, 30(12): 3075-3082.
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Results The number of subjects included in the study A total of 49 patients with early-stage stroke were screened, of whom 32 met the eligibility criteria and were randomized to undergo the intervention, as illustrated in Figure 4. A comparison of baseline characteristics, presented in Tables 1 and 2, revealed no statistically significant differences in demographic or clinical features among the participants (P > 0.05). "
Analysis of differences in outcome indicators among groups of subjects Changes in the indicators after 4 weeks of intervention in the control group and experimental group are shown in Figures 5–7. After 4 weeks, the MAS scores exhibited minimal changes in both groups. The experimental group showed a slight but statistically significant increase (from 5.91 to 6.13, P < 0.05, d=|0.15|), whereas the control group demonstrated a substantial increase (from 5.81 to 7.81, P < 0.05, d=|1.48|). Post-intervention, the MAS scores in the control group were significantly higher than those in the experimental group (7.81 vs. 6.13, P < 0.05, d=|1.11|). Among the spatiotemporal gait parameters assessed, the experimental group displayed highly significant and clinically meaningful improvements in gait velocity (from 16.5 to 38.44 cm/s, P < 0.05, effect size d=|4.01|), step frequency (from 46.44 to 64.94 steps/min, P < 0.05, d=|2.32|), and stride length (from 15.50 to 29.81 cm, P < 0.05, d=|3.44|). In contrast, the control group exhibited changes of greater magnitude but with moderate effect sizes (d=|1.35| to |1.73|) for the same parameters post-intervention."
Both groups demonstrated statistically significant improvements in peak flexion angles of the hip and knee joints (P < 0.05), along with significant reductions in both bilateral and non-paretic support phases (P 0.05). Following a 4-week intervention, the EG demonstrated statistically significant improvements in gait parameters compared to the CG. Specifically, EG exhibited a 28.6% increase in walking velocity (from 26.63 cm/s to 38.44 cm/s; P < 0.05), with a very large treatment effect size (d=|2.75|). Additionally, EG showed significant and substantial increases in other kinematic outcomes: Stride length increased by 25.3% (from 22.31 cm to 29.81 cm; P < 0.05, d=|1.45|), peak hip flexion improved by 33.5% (from 19.44° to 29.25°; P < 0.05, d=|1.31|), and peak knee flexion increased by 25.9% (from 25.25° to 34.06°; P < 0.05, d = 1.42). Moderate yet statistically significant differences were observed in temporal-spatial parameters. Specifically, step frequency exhibited a significant increase (64.94 steps/min vs. 59.38 steps/min; P < 0.05, d=|0.85|). Concurrently, the support phase decreased significantly: bilaterally, it was reduced from 28.375% to 24.31% (P < 0.05, d=|0.88|), and in the non-paretic side, it decreased from 70.13% to 66.19% (P < 0.05, d=|0.94|). Adverse reaction analysis None of the test subjects experienced adverse reactions during the trial."
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