Chinese Journal of Tissue Engineering Research ›› 2026, Vol. 30 ›› Issue (12): 3075-3082.doi: 10.12307/2026.664

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Early intelligent active assistance in walking for hemiplegic patients under suspension protection: #br# a randomized controlled trial

Ma Shanxin1, Zheng Jianling2, Cheng Jian1, Lin Xi1, Li Qiuyuan1, Wang Li1, Zeng Yangkang1, Song Luping3   

  1. 1Department of Rehabilitation Medicine, Shenzhen University General Hospital, Shenzhen 518055, Guangdong Province, China; 2Department of Physical Therapy, Beijing Bo’ai Hospital, China Rehabilitation Research Center, Beijing 100068, China; 3Department of Rehabilitation Medicine, Shenzhen Nanshan People’s Hospital, Shenzhen 518300, Guangdong Province, China 
    Ma Shanxin, MS, Associate chief physician, Department of Rehabilitation Medicine, Shenzhen University General Hospital, Shenzhen 518055, Guangdong Province, China
  • Received:2025-04-02 Accepted:2025-08-06 Online:2026-04-28 Published:2025-09-30
  • Contact: Song Luping, PhD, Chief physician, Department of Rehabilitation Medicine, Shenzhen Nanshan People’s Hospital, Shenzhen 518300, Guangdong Province, China
  • About author:Zheng Jianling, Department of Physical Therapy, Beijing Bo’ai Hospital, China Rehabilitation Research Center, Beijing 100068, China Ma Shanxin and Zheng Jianling contributed equally to this work.
  • Supported by:
    Shenzhen Nanshan District Science and Technology Development Plan Project, No. NS2022150 (to MSX)

Abstract: BACKGROUND: Hemiplegia, a prevalent stroke-related condition, is often studied for motor dysfunction; however, spasticity remains under-researched. Abnormal muscle tone significantly hinders hemiplegic patients’ walking recovery.
OBJECTIVE: To determine whether early suspension-protected training with a personal assistant machine for stroke patients enhances walking ability and prevents muscle spasms.
METHODS: Thirty-two early-stage stroke patients from Shenzhen University General Hospital and the China Rehabilitation Research Center were randomly assigned to the experimental group (n=16) and the control group (n=16). Both groups underwent 4 weeks of gait training under the suspension protection system for 30 minutes daily, 5 days a week. The experimental group used the personal assistant machine during training. Three-dimensional gait analysis (using the Cortex motion capture system), Brunnstrom staging, Fugl-Meyer Assessment for lower limb motor function, Fugl-Meyer balance function, and the modified Ashworth Scale were evaluated within 1 week before the intervention and after 4 weeks of intervention.
RESULTS AND CONCLUSION: After the 4-week intervention, all outcome measures showed significant changes in each group. The experimental group had a small but significant increase in the modified Ashworth Scale score (P < 0.05, d=|0.15|), while the control group had a large significant increase (P < 0.05, d=|1.48|). The experimental group demonstrated greater improvements in walking speed (16.5 to 38.44 cm/s, P < 0.05, d=|4.01|), step frequency (46.44 to 64.94 steps/min, P < 0.05, d=|2.32|), stride length (15.50 to 29.81 cm, P < 0.05, d=|3.44|), and peak hip and knee flexion (d=|1.82| to |2.17|). After treatment, the experimental group showed significantly greater improvements than the control group in walking speed (38.44 vs. 26.63 cm/s, P < 0.05, d=|2.75|), stride length, peak hip and knee flexion (d=|1.31| to |1.45|), step frequency (64.94 vs. 59.38 steps/min, P < 0.05, d=|0.85|), and a reduced support phase (bilateral: 24.31% vs. 28.38%, P < 0.05, d=|0.88|; non-paretic: 66.19% vs. 70.13%, P < 0.05, d=|0.94|). For early hemiplegia, personal assistant machine-assisted gait training under the suspension protection system helps establish a correct gait pattern, prevents muscle spasms, and improves motor function. 

Key words: hemiplegia, stroke, suspension protection system, personal assistant machine, intelligent walking aid, early rehabilitation, active training, walking function, , neuroplasticity,  gait analysis,  motor function recovery,  rehabilitation training,  balance ability

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