Chinese Journal of Tissue Engineering Research ›› 2024, Vol. 28 ›› Issue (14): 2290-2296.doi: 10.12307/2024.279
Dai Xinyu1, Yan Jihong2, Bi Xuecui1, Zheng Xiaohong1
Received:
2023-02-22
Accepted:
2023-04-06
Online:
2024-05-18
Published:
2023-07-28
Contact:
Zheng Xiaohong, PhD, Professor, Doctoral supervisor, Capital University of Physical Education and Sports, Beijing 100191, China
About author:
Dai Xinyu, PhD candidate, Capital University of Physical Education and Sports, Beijing 100191, China
Supported by:
CLC Number:
Dai Xinyu, Yan Jihong, Bi Xuecui, Zheng Xiaohong. Effects of mask-wearing exercise on heart rate, blood oxygen saturation and end-expiratory carbon dioxide: a Meta-analysis[J]. Chinese Journal of Tissue Engineering Research, 2024, 28(14): 2290-2296.
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2.3 纳入研究的干预特征 25篇纳入文献均报道了口罩的型号、材质及用途,纳入文献中涉及恒定强度运动、递增强度运动和抗阻运动,其中恒定强度运动包括6 MWT、1.7 km/h的步行和2.5 km/h的步行;递增强度运动包括跑步、功率自行车、测功仪运动;抗阻运动主要包括器械或克服自身体质量的力量练习。运动时间6-180 min,其中最常用的为递增负荷运动测试。 2.4 纳入文献质量评价结果 在纳入的25项研究中,PEDro量表的得分为6-8分,平均6.16分,整体研究质量较好,见表2。研究被试纳入条件明确,被试能够按分配方案完成试验,测量报告比较完整,由于试验组均采取口罩进行干预,24项研究未能实现对测试者施盲。"
为了进一步探讨潜在异质性来源,对潜在调节变量进行亚组分析结果见表3。按运动强度进行分析,低强度组的异质性检验结果显示,研究间存在较高异质性,采用随机效应模型统计合并效应量,差异无显著性意义,表明佩戴口罩进行低强度运动,不会对心率产生负面作用;中等强度组的研究间存在低异质性,采用固定效应模型合并效应量,结果无显著性意义;高强度组的研究间不存在异质性,采用固定效应模型合并效应量,结果具有显著性意义,表明佩戴口罩进行高强度运动,会对心率产生负面作用;按照持续时间进行亚组分析,≤10 min运动组异质性检验结果显示,佩戴口罩进行短时间运动不会对心率产生负面影响;11-40 min运动组的异质性检验结果显示,研究间存在低度异质性,采用随机效应模型合并效应量,结果无显著性意义。> 40 min运动组异质性检验结果显示,研究间存在高度异质性,采用随机效应模型统计合并效应量,差异无显著性意义。"
2.5.2 佩戴口罩对受试者血氧饱和度的影响 共19项研究以血氧饱和度为结局指标并报告了佩戴口罩运动对于该指标的影响[7-15,17-23,22,26,29],见图5。异质性检验发现研究间存在高度的异质性(I2=96.41 > 50%,P=0.00),敏感性分析逐一剔除纳入研究,发现血氧饱和度指标的异质性主要来自LIU等[17] 和AKGüL等[26]的研究,剔除该研究后异质性降低(Q=24.98,I2=2.97%),且效应量方向无变化。Egger检验结果(P=0.025)与漏斗图均提示了存在着非常显著的发表偏倚,见图6,用剪补法对发表偏倚进行校正后效应值略有降低,但方向并未发生变化,其效应量值为-0.13(95%CI:-0.24至-0.02)。"
2.5.3 佩戴口罩对受试者呼气末二氧化碳的影响 共9项研究以呼气末二氧化碳为结局指标并报告了佩戴口罩运动对于该指标的影响[2,8-10,18,21-22,27,30]。对其进行异质性检验发现研究间存在中度的异质性,选用随机效应模型合并结果。Meta分析结果如图7所示,合并SMD=0.60(95%CI:0.37-0.83,P=0.00),结果表明,佩戴口罩运动对呼气末二氧化碳的影响明显。Egger检验及漏斗图发现纳入研究存在明显的发表偏倚(P=0.00),见图8。为保证研究结果的可靠性,采用逐个排除的方法和固定效应模型与随机效应模型互换的方法进行敏感性分析,剔除RUDI等[30]的研究后,异质性显著下降(I2=0%,P=0.22),但效应量未见显著变化,研究结果可靠。"
2.6 敏感性分析结果 为进一步探究文献异质性的来源,文章对血氧饱和度指标进行敏感性分析结果显示,剔除LIU等[17]和AKGüL等[26]中任一研究均会改变总效应量,详见表6;剔除上述研究后,异质性I2从96.62%降至2.77%,且试验组运动中血氧饱和度仍低于对照组,差异具有显著性意义。第1项研究中运动测试的持续时间较长、其运动场所为室外可能是异质性的原因,被试在运动测试起始时的血氧饱和度为97.78%-98.22%,运动末期降低至95.47%,试验组与对照组的差异虽有显著性意义,但该值并不代表人体出现了低血氧症。第2项研究以大学生为受试者进行了100 min的伏案工作测试。分析认为,伏案工作与运动区别较大,运动中的被试倾向于主动调整呼吸策略,采取“深而慢”的呼吸进行运动,而坐姿学习的受试者更倾向于采用常规的和相对表浅的呼吸方式,由此导致了肺泡通气量的降低。剔除导致异质性来源的研究后,结局指标合并结果未发生方向性转变,提示Meta分析结果稳定。虽然研究异质性客观存在,但未影响最终统计学结果,为反映研究真实性,在分析时仍保留相关研究,未进行排除。"
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