中国组织工程研究

中国组织工程研究

• 组织构建综述 tissue construction review • 上一篇    下一篇

内皮祖细胞与动脉瘤的发生与发展

梁超杰1，闵国文2，郭  庚1   

  1. 山西医科大学第一医院，1神经外科，2神经内科，山西省太原市  030001
  • 修回日期:2013-10-16 出版日期:2013-12-10 发布日期:2013-12-10
  • 通讯作者: 郭庚，博士，副主任医师，硕士生导师。山西医科大学第一医院神经外科，山西省太原市 030001 guogeng973@163.com
  • 作者简介:梁超杰★，男，1990年生，山西省介休市人，汉族，山西医科大学第一医院神经外科在读硕士，主要从事脑血管病研究。 liangchaojie8@126.com
  • 基金资助:

    山西省高等学校创新人才支持计划资助项目*

Endothelial progenitor cells and occurrence and development of aneurysm

Liang Chao-jie1, Min Guo-wen2, Guo Geng1   

  1. 1Department of Neurosurgery, 2Department of Neurology, the First Hospital, Shanxi Medical University, Taiyuan  030001, Shanxi Province, China
  • Revised:2013-10-16 Online:2013-12-10 Published:2013-12-10
  • Contact: Guo Geng, M.D., Associate chief physician, Master’s supervisor, Department of Neurosurgery, the First Hospital, Shanxi Medical University, Taiyuan 030001, Shanxi Province, China guogeng973@163.com
  • About author:Liang Chao-jie★, Studying for master’s degree, Department of Neurosurgery, the First Hospital, Shanxi Medical University, Taiyuan 030001, Shanxi Province, China liangchaojie8@126.com
  • Supported by:

    the Program for the Innovative Talents of Higher Learning Institutions of Shanxi Province*

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摘要：

背景：内皮祖细胞具有修复血管损伤及预测早期血管损伤程度的功能。这一生物学特性被引入到动脉瘤的研究之中，为动脉瘤的发生、发展、早期诊断及治疗提供新的思路。
目的：从内皮祖细胞的生物学特性(增殖、迁移、黏附、衰老)及其在外周循环血中的数量和内皮祖细胞用于动脉瘤的相关临床实验资料进行总结分析。
方法：以“内皮祖细胞、前体细胞、动脉瘤、干细胞”，“ endothelial progenitor cells、precursor、aneurysm、stem cell”为检索词，应用计算机检索期刊万方数据库、中国知网(CNKI)数据库及Pubmed数据库、Springer数据库，Sciencedirect数据库、Ovid数据库。排除与动脉瘤研究无关或内容重复的文献，对纳入文献做进一步分析。
结果与结论：动脉瘤患者的外周循环血中内皮祖细胞数量减少并伴有功能受损。在接受动脉瘤的相关治疗后内皮祖细胞数量上升。内皮祖细胞可早期预测动脉瘤的发生、发展和破裂，也可作为一种治疗方法去阻止动脉瘤的发生。如何将内皮祖细胞广泛的应用到临床当中去预防和防止动脉瘤的发生发展是亟待解决的问题。



中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程


全文链接：

关键词: 组织构建, 组织构建综述, 内皮祖细胞, 动脉瘤, 颅内动脉瘤, 颈动脉瘤, 胸主动脉瘤, 腹主动脉瘤, 干细胞, 生物学特性, 省级基金

Abstract:

BACKGROUND: Endothelial progenitor cells can be used to repair vascular injuries and predict severity of early vascular injuries. These biological characteristics have been recommended to the research of aneurysm, which provide new ideas for studying the occurrence, expansion and early staging diagnosis of aneurysm.
OBJECTIVE: To elaborate the effects of endothelial progenitor cells on the aneurysm in the clinical trials based on the biological characteristics of endothelial progenitor cells, including proliferation, migration, adherence and senescence.
METHODS: A computer-based search of Wanfang, CNKI, Springer, PubMed, ScienceDirect, and Ovid was performed using the keywords of “endothelial progenitor cells, precursor cell, aneurysm, stem cell”. Irrelevant and repetitive articles were excluded, and the result analysis was conducted.
RESULTS AND CONCLUSION: Aneurysms patients display decreased endothelial progenitor cells in the peripheral circulating blood accompanied by functional impairment. After aneurysm-related treatment, the number of endothelial progenitor cells can increase. Application of endothelial progenitor cells can early predict occurrence, development, and rupture of aneurysms, which is also a therapeutic method to prevent aneurysms.How endothelial progenitor cells are used clinically to prevent occurrence and development of aneurysms is a serious problem to be solved.



中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程


全文链接：

Key words: endothelial cells, aneurysm, stem cells, biology