中国组织工程研究

中国组织工程研究 ›› 2026, Vol. 30 ›› Issue (28): 7456-7464.doi: 10.12307/2026.650

• 组织工程相关大数据分析 Big data analysis in tissue engineering • 上一篇    下一篇

核因子κB激活激酶在自身免疫、肿瘤防治等领域的研究脉络与趋势

徐灿丽，何文星，王玉萍，巴寅颖，迟  莉，王文娟，王佳佳   

  1. 首都医科大学中医药学院，北京市  100069
  • 收稿日期:2025-06-30 修回日期:2025-11-12 出版日期:2026-10-08 发布日期:2026-02-26
  • 通讯作者: 王佳佳，博士，副教授，首都医科大学中医药学院，北京市 100069
  • 作者简介:徐灿丽，女，1999年生，首都医科大学在读硕士，主要从事中医药治疗溃疡性结肠炎的病理机制研究。
  • 基金资助:
    国家自然科学基金项目(82104765)，项目负责人：王佳佳；北京中医药薪火传承新3+3工程首批培育类冯建春“三名”传承工作室(2023-SZ-F-16)，项目负责人：杨鑫，王佳佳

Research context and trend of TANK binding kinase 1 in autoimmunity and tumor prevention and treatment

Xu Canli, He Wenxing, Wang Yuping, Ba Yinying, Chi Li, Wang Wenjuan, Wang Jiajia   

  1. School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China
  • Received:2025-06-30 Revised:2025-11-12 Online:2026-10-08 Published:2026-02-26
  • Contact: Wang Jiajia, PhD, Associate professor, School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China
  • About author:Xu Canli, MS candidate, School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China
  • Supported by:
    National Natural Science Foundation of China, No. 82104765 (to WJJ); the First Batch of Beijing Traditional Chinese Medicine Flame Inheritance New 3+3 Project (Cultivation Category) - Feng Jianchun “Sanming” Inheritance Workshop, No. 2023-SZ-F-16 (to YX and WJJ)

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摘要：



文题释义：
核因子κB激活激酶：在炎症因子产生、先天免疫反应、细胞增殖分裂、细胞死亡、细胞自噬、线粒体代谢等过程中发挥着重要的作用。新近研究发现，核因子κB激活激酶帮助肿瘤细胞逃脱机体免疫监视，参与许多自身免疫系统疾病。因此，深入挖掘核因子κB激活激酶的潜在作用机制，是未来医学领域的重要研究方向。
文献计量学：是一门融合了数学、文献信息学、统计学的综合学科。主要通过CiteSpace软件从时间、空间等多角度深入挖掘文献的详细信息，并且以可视化的方式展示文献体系和计量特征，从而揭示科学研究的发展动向，分析热点演变，为科学研究提供参考。

背景：肿瘤双向调控因子核因子κB激活激酶的研究成果逐年增多，但是却没有相关文献计量学分析。
目的：通过文献计量学分析肿瘤逃避因子核因子κB激活激酶的研究现状、热点及趋势。 
方法：基于Web of Science核心合集中的SCIE数据库筛选近10年来核因子κB激活激酶相关研究文献，导入CiteSpace 6.3.R1软件中分别以国家(地区)、作者、机构、参考文献和关键词5个选项进行文献计量及可视化分析，并运用Origin 2021软件绘制相关统计图。
结果与结论：核因子κB激活激酶的发文量、文献共被引次数呈现上升的趋势，Chen，Dan-Dan、Gui，Jian-Fang、Qin，Qiwei和Li，Shun 4位作者发文量最多(11篇)，中国科学院、中国科学院大学、浙江大学、中国农业科学院、武汉大学的发文量较大(> 50篇)。近10年来关于核因子κB激活激酶的研究热点主要集中在innate immunity、cGAS-STING pathway、NF-κB、inflammation、optineurin、expression、cancer等模块。结果表明，近年来各国学者在相关领域进行了持续且深入的研究，核因子κB激活激酶在自身免疫系统、信号通路、基因表达、肿瘤防治等方面显示出巨大的科研潜力。但是学者之间、机构之间的学术合作并不紧密，今后学者应加强合作与交流，把握核因子κB激活激酶的研究热点与趋势，拓展在疾病领域中的研究范围，为进一步阐明疾病的药效机制和病理变化提供更多证据。

https://orcid.org/0000-0003-3816-4249(徐灿丽)


中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

关键词: TANK结合激酶1(TBK1), 核因子κB激活激酶, CiteSpace, Web of Science, 文献计量学, 可视化, 共被引, 研究热点, 前沿

Abstract: BACKGROUND: The research results on TANK binding kinase 1, a bi-directional tumor regulator, have been increasing yearly, but there is no bibliometric literature to analyze the information in the literature related to TANK binding kinase 1.
OBJECTIVE: To explore the research status, hot spots, and trends of TANK binding kinase 1 based on bibliometric analysis. 
METHODS: We collected literature related to TANK binding kinase 1 in the last 10 years based on the SCIE database in the Web of Science Core Collection. The data were imported into CiteSpace 6.3.R1 and analyzed bibliometrically and visually with five options: country, author, institution, reference, and keyword. In addition, Origin 2021 was used to plot the relevant statistical graphs. 
RESULTS AND CONCLUSION: There was an upward trend in the number of publications and co-citations involved in TANK binding kinase 1 research. Dan-Dan Chen, Jian-Fang Gui, Qiwei Qin, and Shun Li were the four authors with the highest number of publications (n=11), while the Chinese Academy of Sciences, University of Chinese Academy of Sciences, Zhejiang University, Chinese Academy of Agricultural Sciences, and Wuhan University had a larger number of publications (> 50). The research hot spots of TANK binding kinase 1 in the last decade mainly focus on innate immunity, the cyclic gmp-amp synthase-stimulator of interferon genes pathway, nuclear factor-κB, inflammation, optineurin, expression, cancer, etc. In recent years, academics from various countries have conducted sustained and in-depth research in related fields. TANK binding kinase 1 shows great potential for research in the autoimmune system, signaling pathways, gene expression, tumor control, and so on. But academic cooperation between academics and between institutions is not strong. In the future, cooperation and communication should be strengthened to grasp the research hot spots and trends of TANK binding kinase 1, to expand its research range in disease areas, and to provide more evidence for further elucidating the pharmacodynamic mechanisms and pathological changes of diseases.


Key words: TANK binding kinase 1 (TBK1), nuclear factor-κB-activated kinase, CiteSpace, Web of Science, bibliometrics, visualization, co-citation, research hotspot, frontier

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