中国组织工程研究

中国组织工程研究 ›› 2026, Vol. 30 ›› Issue (34): 9088-9094.doi: 10.12307/2026.865

• 组织工程相关大数据分析 Big data analysis in tissue engineering • 上一篇    下一篇

脑类器官医学研究未来：跨学科融合培养与生物工程技术及优化模型成熟度

何人大1，马  威2，孙永思1，莫雪妮2   

  1. 广西中医药大学，1第一临床医学院，2发展规划处，广西壮族自治区南宁市  530200
  • 收稿日期:2025-10-29 修回日期:2026-01-22 出版日期:2026-12-08 发布日期:2026-04-15
  • 通讯作者: 莫雪妮，博士，教授，硕士研究生导师，广西中医药大学发展规划处，广西壮族自治区南宁市 530200
  • 作者简介:何人大，男，1989年生，在读硕士，主要从事中医内科学脑病、老年病方向研究。
  • 基金资助:
    国家自然科学基金面上项目(81874453)，项目负责人：莫雪妮；广西自然科学基金项目(2020GXSFAA297270)，项目负责人：莫雪妮；广西中医药大学青年基金项目(2023QN006)，项目负责人：马威；广西中医药大学校级重点项目(2024ZD006)，项目负责人：莫雪妮

Future medical research on brain organoids: interdisciplinary training, bioengineering technologies, and optimized model maturity

He Renda1, Ma Wei2, Sun Yongsi1, Mo Xueni2   

  1. 1The First Clinical Medical College of Guangxi University of Chinese Medicine, Nanning 530200, Guangxi Zhuang Autonomous Region, China; 2Development Planning Office of Guangxi University of Chinese Medicine, Nanning 530200, Guangxi Zhuang Autonomous Region, China
  • Received:2025-10-29 Revised:2026-01-22 Online:2026-12-08 Published:2026-04-15
  • Contact: Mo Xueni, PhD, Professor, Master’s supervisor, Development Planning Office of Guangxi University of Chinese Medicine, Nanning 530200, Guangxi Zhuang Autonomous Region, China
  • About author:He Renda, MS candidate, The First Clinical Medical College of Guangxi University of Chinese Medicine, Nanning 530200, Guangxi Zhuang Autonomous Region, China
  • Supported by:
    National Natural Science Foundation of China (General Program), No. 81874453 (to MXN); Guangxi Natural Science Foundation, No. 2020GXSFAA297270 (to MXN); Guangxi University of Chinese Medicine Youth Fund, No. 2023QN006 (to MW); Guangxi University of Chinese Medicine Key Project, No. 2024ZD006 (to MXN)

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摘要：



文题释义：
脑类器官：是一种体外培育出的模拟人脑发育和功能的三维模型，在神经疾病病理机制解析(如神经发育障碍与神经退行性疾病)、脑损伤修复、神经毒性评估及脑疾病药物筛选等领域展现出了广阔的应用场景。
文献计量学：作为一种科学且高效的文献分析方法，通过可视化展示和系统性分析，能够清晰、直观地呈现国家、机构、期刊、作者、关键词、文献等具体信息，揭示研究领域的发展趋势和热点。

背景：近年来，脑类器官迅速成为神经医学研究的热点，却未见脑类器官医学研究相关知识图谱的整体性分析。
目的：通过文献计量学分析，对脑类器官医学研究领域的研究热点、最新动态以及发展趋势进行梳理与总结，为学者提供快速、系统的领域概览。
方法：检索Web of Science核心数据库中2014-01-01/2024-12-31脑类器官领域的相关文献，使用Citespace、Microsoft Office以及Origin软件对脑类器官研究的发文量、国家分布、机构贡献、作者、高被引文献及关键词热点等进行系统分析。
结果与结论：脑类器官医学研究领域的发文量呈现持续快速增长趋势，美国的发文量及影响力居首；加州大学系统为最高产出机构，大部分机构之间合作交流频繁，形成了广泛的合作网络，研究团队内部联系紧密，但团队间合作较少；发文量最多的作者是Knoblich J；2021年后研究热点进入集中爆发期，长期研究热点为pluripotent stem cells (多能干细胞)、in vitro model(体外模型)、culture (培养)，近年热点研究方向为choroid plexus (脉络丛)、human cortical organoids (人类皮质类器官)以及microglia(小胶质细胞)。结果表明，脑类器官医学研究领域近年来进入快速发展的新阶段，具有较高的主题多样性，体外三维模型培养一直是研究热点，后续研究将聚焦于跨学科融合脑类器官培养与生物工程技术，优化模型成熟度，为再生医学、脑疾病治疗及神经医学机制探索提供精准的体外研究平台。

https://orcid.org/0009-0004-1304-566X(何人大)


中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

关键词: 脑类器官, 文献计量学, 可视化, 跨学科融合, Citespace

Abstract: BACKGROUND: In recent years, brain organoids have rapidly emerged as a hotspot in neuroscience research; however, no comprehensive analysis of knowledge graphs related to medical research on brain organoid has been conducted.
OBJECTIVE: To conduct a bibliometric analysis of brain organoid medical research and systematically collate research hotspots, emerging trends, and developmental trajectories in this field, thereby providing scholars with a rapid and systematic overview of the current landscape. 
METHODS: Relevant publications on brain organoids from January 1, 2014 to December 31, 2024 were retrieved and analyzed using the Web of Science Core Collection. CiteSpace, Microsoft Office, and Origin software were employed to quantify annual publication volume, country distributions, institutional contributions, author productivity, highly cited literature, and keyword co-occurrence networks. 
RESULTS AND CONCLUSION: The annual publication volume in brain organoid medicine research has demonstrated a rapid growth trajectory. The United States dominated both output and academic influence, with the University of California System emerging as the most prolific institution. While extensive collaborative networks were observed among institutions and intra-team collaborations remained close-knit, inter-team partnerships were limited. The highest-output author was Knoblich J. Since 2021, research hotspots entered an intensive growth phase. Persistent themes included pluripotent stem cells, in vitro models, and culture techniques, while recent frontiers shifted toward choroid plexus, human cortical organoids, and microglia. To conclude, medical research on brain organoids has entered a phase of accelerated innovation characterized by thematic diversity. The establishment of in vitro three-dimensional models remains a central priority. Future research will focus on interdisciplinary integration of organoid culture with bioengineering technologies to optimize model maturity, thereby advancing precision platforms for investigations on regenerative medicine, neurological disorder treatment, and neurophysiological mechanisms.

Key words: brain organoids, bibliometrics, visualization, interdisciplinary integration, CiteSpace

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