中国组织工程研究

中国组织工程研究 ›› 2026, Vol. 30 ›› Issue (32): 8569-8576.doi: 10.12307/2026.874

• 生物材料相关大数据分析 Big data analysis of biomaterials • 上一篇    

聚醚醚酮材料在颅骨缺损修复中的应用与发展

张占阅1，2，3，赵立军1，2，3，张春阳1，2，3，张中奇1，2，3，付  康1，2，3，张志红1   

  1. 1内蒙古科技大学包头医学院第一附属医院，内蒙古自治区包头市  014010；2包头医学院神经外科疾病研究所(转化医学)，内蒙古自治区包头市  014010；3内蒙古自治区骨组织再生与损伤修复工程技术中心，内蒙古自治区包头市  014010
  • 接受日期:2026-01-29 出版日期:2026-11-18 发布日期:2026-04-29
  • 通讯作者: 张志红，内蒙古科技大学包头医学院第一附属医院，内蒙古自治区包头市 014010
  • 作者简介:张占阅，男，1990年生，内蒙古自治区包头市人，汉族，2018年内蒙古科技大学包头医学院毕业，硕士，主治医师，主要从事个性化与精准医疗研究。 赵立军，男，1981年生，内蒙古自治区包头市人，汉族，2009年内蒙古科技大学包头医学院毕业，硕士，主任医师，主要从事神经再生与修复研究。
  • 基金资助:

Application and development of polyetheretherketone material in skull defect repair

Zhang Zhanyue1, 2, 3, Zhao Lijun1, 2, 3, Zhang Chunyang1, 2, 3, Zhang Zhongqi1, 2, 3, Fu Kang1, 2, 3, Zhang Zhihong1   

  1. 1First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou 014010, Inner Mongolia Autonomous Region, China; 2Institute of Neurosurgical Diseases (Translational Medicine) of Baotou Medical College, Baotou 014010, Inner Mongolia Autonomous Region, China; 3Engineering Technology Center for Bone Tissue Regeneration and Injury Repair in Inner Mongolia Autonomous Region, Baotou 014010, Inner Mongolia Autonomous Region, China
  • Accepted:2026-01-29 Online:2026-11-18 Published:2026-04-29
  • Contact: Zhang Zhihong, First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou 014010, Inner Mongolia Autonomous Region, China
  • About author:Zhang Zhanyue, MS, Attending physician, First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou 014010, Inner Mongolia Autonomous Region, China; Institute of Neurosurgical Diseases (Translational Medicine) of Baotou Medical College, Baotou 014010, Inner Mongolia Autonomous Region, China; Engineering Technology Center for Bone Tissue Regeneration and Injury Repair in Inner Mongolia Autonomous Region, Baotou 014010, Inner Mongolia Autonomous Region, China Zhao Lijun, MS, Chief physician, First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou 014010, Inner Mongolia Autonomous Region, China; Institute of Neurosurgical Diseases (Translational Medicine) of Baotou Medical College, Baotou 014010, Inner Mongolia Autonomous Region, China; Engineering Technology Center for Bone Tissue Regeneration and Injury Repair in Inner Mongolia Autonomous Region, Baotou 014010, Inner Mongolia Autonomous Region, China

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摘要：

文题释义：
聚醚醚酮：是一种热塑性高分子聚合物材料，因具有优异的高耐热性能、较高的力学强度、优良的抗化学腐蚀性能、较低的摩擦系数以及良好的生物相容性等特点，被广泛应用于医疗器械制造业中(例如颅骨修补、牙科修复)，是一种可以部分代替金属材料的新型高分子聚合物材料。
文献计量学：应用数学和统计学的方法来衡量学术文献及与之相联系的某些属性(数量、作者、机构、期刊、引用、关键词、合作等)，并以此为基础开展定量分析的研究。通过对文献信息的数量、空间分布、重点领域、发展趋势等情况进行分析，发现科学知识产生的源泉、产生的场所、传播的流向等，探索学科发展规律，把握某一学科的整体发展态势以及研究最前沿。

背景：聚醚醚酮合成材料由于具有密度小、强度高、韧性好、加工性能优异以及生物相容性好等优点，已经成为修复颅骨缺损的首选材料之一，但对聚醚醚酮用于颅骨修复的文献计量学分析却很少。
目的：运用文献计量学手段探讨聚醚醚酮材料在国际颅骨缺损修复领域的整体研究态势、发展脉络、研究重点及热点。
方法：在Web of Science核心合集数据库系统检索1995-2024年收录的聚醚醚酮材料修复颅骨缺损的文献。在此基础上，采用文献计量学方法从发文量的时间动态、国家/地区贡献力、核心研究机构合作网络、高被引论文、高产期刊及关键词共现等方面开展定量统计及可视化分析。
结果与结论：此研究分析2009-2024年发表的105篇聚醚醚酮修复颅骨缺损研究，发展过程大致分为3个阶段：2009-2014年传统材料、2015-2019年聚醚醚酮临床研究、2020-2024年3D打印、有限元分析，其中2020-2024年阶段占比42%。同时，“3D打印、有限元分析”“聚醚醚酮、钛合金”为高频技术组合。中国(21篇)、美国(17篇)、德国(12篇)为主要研究国家。聚醚醚酮全球临床应用超过20万例，感染率为3.7%，低于聚甲基丙烯酸甲酯的9.2%。聚醚醚酮研究从“被动修复”转向“主动生物活性促进”。欧美地区3D打印临床转化领先(设备配备率82%，中国国内为39%)，但3D打印聚醚醚酮存在约2年文献与临床之间的滞后期。预测导电聚醚醚酮将于2026-2027年加速转化。结果表明，聚醚醚酮已实现从“被动修复”到“主动生物活性促进”的转变，3D打印、表面改性、智能集成是核心方向。全球聚醚醚酮发展不均衡，欠发达地区需求高但研究较少(12%)，中国国内侧重临床研究(68%)，基础创新不足(15%)，需要推广低成本3D打印技术，建立转化枢纽，支持跨学科研究团队，构建10年多中心随访体系。
https://orcid.org/0009-0001-4519-9610(张志红)

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料；口腔生物材料；纳米材料；缓释材料；材料相容性；组织工程

关键词: 颅骨缺损, 聚醚醚酮, 文献计量学, Web of Science, 3D打印, 有限元分析, 生物相容性, 颅骨成形术

Abstract: BACKGROUND: Polyetheretherketone, a high-performance synthetic material prized for its low density, high strength, excellent toughness, favorable processing characteristics, and biocompatibility, is still becoming a primary choice for repairing skull defects. However, systematic bibliometric studies specifically analyzing its application in cranial repair are scarce. 
OBJECTIVE: To summarize the overall research trend, development trajectory, research focus, and hotspots of polyetheretherketone materials in the field of skull defect repair internationally using bibliometric methods.
METHODS: The Web of Science Core Collection database system was searched for the literature on the application of polyetheretherketone materials in skull defect repair from 1995 to 2024. Subsequently, quantitative statistical and visual analyses were performed using bibliometric techniques, focusing on temporal trends in publication volume, contributions by country/region, collaborative networks of core research institutions, highly cited papers, prolific journals, and keyword co-occurrence.
RESULTS AND CONCLUSION: In this work, we analyzed 105 articles on polyetheretherketone for skull defect repair covering 2009 to 2024. We found that the field was divided into three phases. From 2009 to 2014, the focus was on traditional materials; from 2015 to 2019, on clinical research of polyetheretherketone; and from 2020 to 2024, on 3D printing and finite element analysis, with the 2020-2024 phase accounting for 42% of the total. Meanwhile, the combinations of “3D printing and finite element analysis” and “polyetheretherketone and titanium alloy” are high-frequency technology pairs. China (21 articles), USA (17 articles), and Germany (12 articles) are the main research countries. Polyetheretherketone has been clinically used in more than 200,000 cases worldwide, with an infection rate of 3.7%, which is lower than the infection rate of 9.2% reported for polymethylmethacrylate. Research on polyetheretherketone has shifted from “passive repair” to “active bioactivity promotion.” Europe and USA are leading the clinical translation of 3D printing (82% device availability versus 39% in China), but there is a lag time of about 2 years between published literature and clinical application for 3D-printed polyetheretherketone. Conductive polyetheretherketone is predicted to accelerate translation from 2026 to 2027. These findings suggest that polyetheretherketone has achieved the transformation from “passive repair” to “active biological activity promotion,” with 3D printing, surface modification, and intelligent integration as the core directions. The global development of polyetheretherketone is uneven, with high demand but less research in underdeveloped regions (12%). China focuses on clinical research domestically (68%) but shows insufficient basic innovation (15%). It is necessary to promote low-cost 3D printing technology, establish transformation hubs, support interdisciplinary teams, and build a 10-year multi-center follow-up system.  


Key words: skull defect, polyetheretherketone, bibliometrics, Web of Science, 3D printing, finite element analysis, biocompatibility, cranioplasty

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