中国组织工程研究

中国组织工程研究 ›› 2025, Vol. 29 ›› Issue (30): 6538-6546.doi: 10.12307/2025.950

• 组织构建综述 tissue construction review • 上一篇    下一篇

脑机接口联合不同疗法治疗脑卒中患者肢体功能障碍：效果与机制分析

王雪淞1，2，3，汪  月1，4，徐  岩1，2，3，曾雯慧1，2，3，卢文明1，2，唐兴坤1，2，陈文杰2，叶俊松1，3，5，6   

  1. 1赣南医科大学第一附属医院干细胞临床转化分中心，江西省赣州市  341000；赣南医科大学，2康复学院，4护理学院，江西省赣州市  341000；3赣州市干细胞与再生医学重点实验室，江西省赣州市  341000；5江西省干细胞与再生医学重点实验室，江西省赣州市  341000；6心脑血管疾病防治教育部重点实验室，江西省赣州市  341000
  • 收稿日期:2024-10-08 接受日期:2024-11-30 出版日期:2025-10-28 发布日期:2025-03-29
  • 通讯作者: 叶俊松，博士，教授，赣南医科大学第一附属医院，江西省赣州市 341000；赣南医科大学第一附属医院干细胞临床转化分中心，江西省赣州市 341000；赣州市干细胞与再生医学重点实验室，江西省赣州市 341000；江西省干细胞与再生医学重点实验室，江西省赣州市 341000；心脑血管疾病防治教育部重点实验室，江西省赣州市 341000
  • 作者简介:王雪淞，男，1998年生，黑龙江省七台河市人，汉族，赣南医科大学在读硕士，主要从事康复治疗学相关研究。
  • 基金资助:
    国家自然科学基金项目(32060232)，项目负责人：叶俊松；江西省自然科学基金面上项目(20212BAB206075)，项目负责人：叶俊松

Brain-computer interface combined with different therapies for limb dysfunction in stroke patients: effectiveness and mechanism analysis

Wang Xuesong1, 2, 3, Wang Yue1, 4, Xu Yan1, 2, 3, Zeng Wenhui1, 2, 3, Lu Wenming1, 2, Tang Xingkun1, 2, Chen Wenjie2, Ye Junsong1, 3, 5, 6   

  1. 1Subcenter for Stem Cell Clinical Translation, First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, Jiangxi Province, China; 2School of Rehabilitation Medicine, 4College of Nursing, Gannan Medical University, Ganzhou 341000, Jiangxi Province, China; 3Ganzhou Key Laboratory of Stem Cell and Regenerative Medicine, Ganzhou 341000, Jiangxi Province, China; 5Jiangxi Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Ganzhou 341000, Jiangxi Province, China; 6Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Ganzhou 341000, Jiangxi Province, China 
  • Received:2024-10-08 Accepted:2024-11-30 Online:2025-10-28 Published:2025-03-29
  • Contact: Ye Junsong, PhD, Professor, Subcenter for Stem Cell Clinical Translation, First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, Jiangxi Province, China; Ganzhou Key Laboratory of Stem Cell and Regenerative Medicine, Ganzhou 341000, Jiangxi Province, China; Jiangxi Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Ganzhou 341000, Jiangxi Province, China; Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Ganzhou 341000, Jiangxi Province, China
  • About author:Wang Xuesong, Master candidate, Subcenter for Stem Cell Clinical Translation, First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, Jiangxi Province, China; School of Rehabilitation Medicine, Gannan Medical University, Ganzhou 341000, Jiangxi Province, China; Ganzhou Key Laboratory of Stem Cell and Regenerative Medicine, Ganzhou 341000, Jiangxi Province, China
  • Supported by:
    National Natural Science Foundation of China, No. 32060232 (to YJS); Natural Science Foundation of Jiangxi Province, No. 20212BAB206075 (to YJS)

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摘要：


文题释义：
脑机接口技术：是一种多学科融合后产生的新型康复治疗技术，涉及神经科学、生物医学工程、计算机技术等多种学科。该技术不依赖人体外周神经传输通路和肌肉组织，并可以在人脑与外界机器之间建立联系，完成信息人机交互。脑机接口可以促进大脑运动区域的神经可塑性，进而改善脑卒中患者肢体运动功能障碍，其主要的范式有3种类型：P300、运动想象和视觉稳态唤起电位。

背景：近年来，脑机接口技术在脑卒中患者的肢体功能障碍康复方面取得了可喜的成果。随着研究的不断深入以及临床上的广泛使用，脑机接口联合其他康复疗法改善患者的肢体功能障碍成为研究热点。
目的：分析和总结脑机接口联合不同疗法对脑卒中患者肢体功能障碍的有效性，探讨不同联合策略在临床上的应用价值。
方法：以“脑机接口，BCI，脑卒中，中风” 为中文检索词，以“Brain-computer interface，BCI，Brain-computer interaction，Brain-machine interface，BMI，Stroke”为英文检索词，在中国知网、万方、维普数据库及PubMed、Embase、Web of Science等中英文数据库进行文献检索，检索时限为各数据库建库起至2024年9月。最终共检索到3 054篇文献，经过筛选后纳入75篇文献进行归纳总结。
结果与结论：目前，临床上除可以单独使用脑机接口技术治疗脑卒中患者肢体功能障碍外，还可以通过联合其他治疗方式获得更好的疗效，如联合中医疗法、康复疗法或物理因子治疗等。然而综合已有的研究发现，脑机接口联合经颅直流电疗法治疗患者上肢及下肢功能障碍的有效性存在争议。当前，研究人员逐渐认识到联合治疗的可行性，但由于治疗机制探索不足，无规范化规则以及样本量过小等因素，导致目前该策略还不具有普遍适用性。因此未来研究应集中于探究脑机接口与其他疗法结合后发挥增益效果的机制，并且规范临床试验的标准，以推动临床上的广泛应用。
https://orcid.org/0009-0001-1816-4981(王雪淞)；https://orcid.org/0000-0003-4336-1933(叶俊松)

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

关键词: 脑机接口, 脑卒中, 功能障碍, 联合治疗, 神经可塑性, 康复工程, 运动想象, 视觉稳态唤起电位

Abstract: BACKGROUND: In recent years, brain-computer interface technology has shown significant promise for rehabilitating limb dysfunction in stroke patients. With ongoing research deepening and its broader clinical application, combining brain-computer interface with other rehabilitation therapies to improve limb function has become a focal point of study. 
OBJECTIVE: To analyze and summarize the efficacy of brain-computer interface combined with various therapies in treating limb dysfunction in stroke patients and to explore the clinical value of these combined strategies.
METHODS: The search terms used for the literature review in Chinese databases were “brain-computer interface, BCI, stroke,” while the terms “brain-computer interface, BCI, brain-computer interaction, brain-machine interface, BMI, stroke” were used for English databases. Literature searches were conducted in CNKI, WanFang, VIP, PubMed, Embase, and Web of Science, from the time of database construction to September 2024. Finally, a total of 3 054 articles were retrieved, and 75 articles were included after screening for summarization. 
RESULTS AND CONCLUSION: Currently, brain-computer interfaces, used alone or in combination with other treatments such as Chinese medical treatment, conventional rehabilitation therapy, or physical factor therapy, are achieving better outcomes in treating limb dysfunction in stroke patients. However, the efficacy of brain-computer interfaces combined with transcranial direct current stimulation for treating upper and lower limb dysfunctions is still debated. Researchers are increasingly recognizing the feasibility of these combined therapies. Yet, challenges such as limited exploration of therapeutic mechanisms, absence of standardized protocols, and small sample sizes hinder their broad application. Future research should therefore focus on understanding the mechanisms by which brain-computer interfaces can enhance effects when combined with other therapies and on standardizing criteria for clinical trials to enable widespread clinical adoption. 

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: brain-computer interface, stroke, dysfunction, combined therapy, neuroplasticity, rehabilitation engineering, motor imagery, visual steady-state evoked potential 

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