中国组织工程研究

中国组织工程研究 ›› 2025, Vol. 29 ›› Issue (21): 4439-4444.doi: 10.12307/2025.159

• 骨与关节生物力学Bone and joint biomechanics • 上一篇    下一篇

发育性髋关节发育不良患者固液双相纤维增强软骨的力学性能

高永昌1，陈鹏飞1，陈瑱贤1，魏  晶2，董  哲1，李  辉3，张志峰2   

  1. 1长安大学工程机械学院，公路养护装备国家工程实验室，陕西省西安市   710064；2内蒙古医科大学第二附属医院关节外科，内蒙古自治区呼和浩特市   010020；3西安市红会医院关节外科，陕西省西安市   710054
  • 收稿日期:2023-12-29 接受日期:2024-03-19 出版日期:2025-07-28 发布日期:2024-12-05
  • 通讯作者: 李辉，副主任医师，西安市红会医院关节外科，陕西省西安市 710054 张志峰，主任医师，内蒙古医科大学第二附属医院关节外科，内蒙古自治区呼和浩特市 010020
  • 作者简介:高永昌，2016年西安交通大学毕业，博士，讲师，硕士生导师，主要从事生物力学和生物摩擦学方面的研究。
  • 基金资助:
    内蒙古自治区自然科学基金项目(2020MS08144)，项目负责人：张志峰

Mechanical properties of solid-liquid biphase fiber-reinforced cartilage in developmental dysplasia of hip patients

Gao Yongchang1, Chen Pengfei1, Chen Zhenxian1, Wei Jing2, Dong Zhe1, Li Hui3, Zhang Zhifeng2   

  1. 1National Engineering Laboratory for Highway Maintenance Equipment, School of Engineering Machinery of Chang’an University, Xi’an 710064, Shaanxi Province, China; 2Department of Joint Surgery, Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010020, Inner Mongolia Autonomous Region, China; 3Department of Joint Surgery, Xi’an Honghui Hospital, Xi’an 710054, Shaanxi Province, China
  • Received:2023-12-29 Accepted:2024-03-19 Online:2025-07-28 Published:2024-12-05
  • Contact: Li Hui, Associate chief physician, Department of Joint Surgery, Xi’an Honghui Hospital, Xi’an 710054, Shaanxi Province, China Zhang Zhifeng, Chief physician, Department of Joint Surgery, Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010020, Inner Mongolia Autonomous Region, China
  • About author:Gao Yongchang, MD, Lecturer, Master’s supervisor, National Engineering Laboratory for Highway Maintenance Equipment, School of Engineering Machinery of Chang’an University, Xi’an 710064, Shaanxi Province, China
  • Supported by:
    Natural Science Foundation of Inner Mongolia Autonomous Region, No. 2020MS08144 (to ZZF)

PDF

25

摘要：

文题释义：

发育性髋关节发育不良：是常见的先天性髋关节疾病，相比正常髋关节，其特点是髋臼、股骨头存在结构、大小及方向等方面的畸形，最终导致股骨头脱位和半脱位等疾病。
固液双相：软骨的固液双相特性是指软骨组织在特定条件下(例如受压或压力释放时)能够呈现固态和液态之间的转变，两部分具有不同的组成特性和功能，这种特性使得软骨具有较好的抗压和吸收冲击的能力。

摘要
背景：发育性髋关节发育不良由于髋臼、股骨头存在结构、大小及方向等方面的畸形，患者长时间活动或站立会引起腹股沟疼痛，如果得不到有效的治疗，患者的正常活动将严重受限。
目的：基于FEBio建立具有固液双相纤维增强软骨的球-窝髋关节有限元模型，探究发育性髋关节发育不良患者和正常人髋关节软骨的生物力学特性。
方法：对1名发育性髋关节发育不良患者和1名正常志愿者进行髋关节建模，模型包含左盆骨、左股骨及附着其上的软骨。验证正常髋关节固液双相纤维增强软骨模型有效性后，建立髋关节发育不良患者髋关节有限元模型，对比两者在单腿站立时(2 130 N静态载荷)软骨的接触应力、流体压力、固相等效应力和流体支撑率的差异。
结果与结论：①与正常髋关节相比，载荷加载完成后1 s(承载初期)，发育性髋关节发育不良患者髋臼软骨出现明显的边缘接触，且峰值接触应力(3.86 MPa)和峰值流体压力(3.76 MPa)均大于正常髋关节软骨；②1 500 s(承载稳定)后，2个模型软骨峰值接触应力和峰值流体压力均减小，但发育性髋关节发育不良患者软骨接触位置由软骨边缘向中心移动，流体支撑率由97.41%下降到91.08%，正常髋关节软骨流体支撑率下降了0.58%，由95.24%下降到94.66%；③提示单腿站立生理载荷下，发育性髋关节发育不良患者软骨出现明显的边缘载荷，其峰值接触应力、流体压力和流体支撑率的下降幅度均大于正常软骨，考虑软骨的固液双相纤维增强特性对于评估髋关节发育不良患者髋关节软骨的生物力学性能、理解髋关节发育不良病理生理机制和制定术前计划具有重要的临床意义。 

中国组织工程研究杂志出版内容重点：人工关节；骨植入物；脊柱；骨折；内固定；数字化骨科；组织工程

关键词: 发育性髋关节发育不良, 软骨, 固液双相纤维增强, 有限元分析, 生物力学

Abstract: BACKGROUND: Developmental dysplasia of hip causes groin pain in patients with prolonged activity or standing due to the presence of deformities of the acetabulum and femoral head in terms of structure, size and orientation, and if not effectively treated, patients’ normal activities will be severely limited. 
OBJECTIVE: Finite element model of the hip joint of solid-liquid biphase fiber reinforced cartilage based on FEBio was established to explore the biomechanical properties of the cartilage for patients with developmental dysplasia of hip and the normal hip joint.  
METHODS: A patient with developmental dysplasia of hip and a normal volunteer were chosen to build their left hip models including left pelvis, left femur, and cartilage attached thereto. The solid-liquid biphase fiber reinforced cartilage of normal hip was verified to be effective. The cartilage equal contact stress, fluid pressure, solid effective stress, and fluid support rate differences between the developmental dysplasia of hip patients hip and the normal one in the case of one leg of static load (2 130 N) were compared after establishing finite element models of developmental dysplasia of hip patients.
RESULTS AND CONCLUSION: (1) Compared with the finite element results of the normal hip model, the cartilage contact position of developmental hip dysplasia patient hip showed obvious edge contact, the peak contact stress (3.86 MPa) and peak fluid pressure (3.76 MPa) were both higher than normal hip model. (2) After 1 500 s (stable load-bearing capacity), peak contact stress and peak fluid pressure in both models decreased, but the cartilage contact position of developmental hip dysplasia patient hip moved from the edge of cartilage to the center, and fluid support rate decreased from 97.41% to 91.08%. The fluid support rate in normal hip was decreased by 0.58% from 95.24% to 94.66%. (3) It is indicated that under the physiological load of standing on one leg, the cartilage of developmental dysplasia of hip patients showed obvious edge load, and the decrease of peak contact stress, fluid pressure, and fluid formation rate was greater than that of normal cartilage. Considering the solid-liquid biphasic fiber reinforcement characteristics of cartilage, it is of great clinical significance to evaluate the biomechanical properties of hip cartilage in developmental dysplasia of hip patients, to understand the pathophysiological mechanism of developmental dysplasia of hip, and make preoperative plan.

中国组织工程研究杂志出版内容重点：人工关节；骨植入物；脊柱；骨折；内固定；数字化骨科；组织工程

Key words: developmental dysplasia of hip, cartilage, solid-liquid biphase fiber reinforcement, finite element analysis, biomechanics

中图分类号: