中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (38): 7131-7134.doi: 10.3969/j.issn.2095-4344.2012.38.021

• 药物控释材料 drug delivery materials • 上一篇    下一篇

ε-己内酯与DL-丙交酯共聚物的体内降解性能

张 巍,杨 丹,王 萍,王 玲,甄 珠   

  1. 辽宁省计划生育科学研究院,辽宁省沈阳市 110031
  • 收稿日期:2012-01-07 修回日期:2012-02-01 出版日期:2012-09-16 发布日期:2012-09-16
  • 通讯作者: 杨丹,研究员,辽宁省计划生育科学研究院,辽宁省沈阳市 110031 yangdan0108@ 126.com
  • 作者简介:张巍★,女,1981年生,硕士,助理研究员,主要从事生物医药高分子材料研究。 zhangweitiny@ sohu.com

Degradability of epsilon-caprolactone and DL-lactide copolymers in vivo

Zhang Wei, Yang Dan, Wang Ping, Wang Ling, Zhen Zhu   

  1. Liaoning Research Institute of Family Planning, Shenyang 110031, Liaoning Province, China
  • Received:2012-01-07 Revised:2012-02-01 Online:2012-09-16 Published:2012-09-16
  • Contact: Yang Dan, Research fellow. Liaoning Research Institute of Family Planning, Shenyang 110031, Liaoning Province, China yangdan0108@ 126.com
  • About author:Zhang Wei★, Master, Researcher, Liaoning Research Institute of Family Planning, Shenyang 110031, Liaoning Province, China zhangweitiny@ sohu.com

摘要:

背景:ε-己内酯与DL-丙交酯共聚后具有良好的生物相容性和可调控的降解速率,它的应用与其体内降解性能有着重要关系。
目的:观察聚(己内酯-co-DL-丙交酯)在大耳白兔体内的降解性能。
方法:将不同配比DL-丙交酯和ε-己内酯组成的聚(己内酯-co-DL-丙交酯)制备成不同尺寸的试样,植入到日本大耳白兔背部皮下,定期观察试样的形态、失重率、相对分子质量和热性能。
结果与结论:随着ε-己内酯投料比的增加,聚(己内酯-co-DL-丙交酯)形状保持能力增强,降解速度减慢;相同共聚组成的试样,尺寸越大,降解速度越快。

关键词: 共聚物, ε-己内酯, DL-丙交酯, 生物降解材料, 体内

Abstract:

BACKGROUND: Copolymers of ε-caprolactone and DL-lactide (PCDLA) have good biocompatibility and adjustable degradation rate. And there is an important relationship between the application of PCDLA and its degradation property in vivo.
OBJECTIVE: To investigate the degradation property of PCDLA in vivo of big ear rabbits.
METHODS: The PCDLA with different copolymer compositions were made into samples with different sizes, and the samples were implanted in the back of Japanese big ear rabbits subcutaneously. The morphology, weight loss rate, number-average molecular weight and thermal properties of the samples were observed regularly. The degradation property of PCDLA in vivo was evaluated.
RESULTS AND CONCLUSION: The results showed that the PCDLA shape retention was enhanced and degradation rate was slowed down with the feed ratio of ε-caprolactone increased. These suggest that for the same copolymer composition of samples, the larger size, and the faster degradation rate.

中图分类号: