中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (52): 9802-9806.doi: 10.3969/j.issn.2095-4344.2012.52.022

• 骨与关节损伤基础实验 basic experiments of bone and joint injury • 上一篇    下一篇

基于吲哚菁绿近红外荧光特性手术影像导航系统的设计

吕铁军，李文科，李凯扬   

  1. 武汉大学物理科学与技术学院，湖北省武汉市 430072
  • 收稿日期:2012-05-22 修回日期:2012-08-05 出版日期:2012-12-23 发布日期:2012-12-23
  • 通讯作者: 李凯扬，博士，教授，博士生导师，主要从事医学影像信息提取以及影像设备开发研究。 lky@whu.edu.cn
  • 作者简介:吕铁军★，男，1988年生，汉族，武汉大学在读硕士，主要从事医疗仪器开发方面的研究。 lvtiejun@whu.edu.cn

Design of the intraoperative imaging navigation system based on the near-infrared fluorescence properties of indocyanine green

Lü Tie-jun, Li Wen-ke, Li Kai-yang   

  1. College of Physical Science and Technology, Wuhan University, Wuhan 430072, Hubei Province, China
  • Received:2012-05-22 Revised:2012-08-05 Online:2012-12-23 Published:2012-12-23
  • Contact: Li Kai-yang, Doctor, Professor, Doctoral supervisor, College of Physical Science and Technology, Wuhan University, Wuhan 430072, Hubei Province, China lky@whu.edu.cn
  • About author:Lü Tie-jun★, Studying for master’s degree, College of Physical Science and Technology, Wuhan University, Wuhan 430072, Hubei Province, China lvtiejun@whu.edu.cn

PDF

1072

被引次数

6

摘要：

背景：近年来，吲哚氰绿因为其独特的物理性质和近红外光谱特性，正在被研究用来进行医学成像。
目的：设计基于吲哚氰绿近红外荧光特性的手术影像导航系统。
方法：依据原理设计光学系统和硬件系统，并开发出相应的软件系统，并利用前期实验进行系统成像效果验证。
结果与结论：传统的方法是通过转换术前特定组织的医学成像信息来提供术中解剖学信息，但是这种方法应用于一些手术中有困难，因此通过手术中成像手段提供术中生物组织信息很重要。利用人体血液在成像系统下进行成像实验的结果显示，基于吲哚氰绿近红外荧光特性的手术影像导航系统对荧光感应度高，对照区分明显，成像效果好，方案可行。

关键词: 吲哚氰绿, 影像导航系统, 近红外荧光, 成像系统, 采集与处理模块, 光谱特性

Abstract:

BACKGROUND: In recent years, indocyanine green has been used in some medical imaging because of its unique physical properties and near-infrared spectral characteristics.
OBJECTIVE: To design an intraoperative imaging navigation system based on the near-infrared fluorescence properties of indocyanine green.
METHODS: The optical part, hardware part and software part were designed according to the principle. The imaging efficacy of system was identified through early experiment.
RESULTS AND CONCLUSION: Conventional method of providing intraoperative anatomical information was used to transfer the preoperative image data of specific tissues to intraoperative situation. However, that was difficult in some cases. So, it was important to provide real-time information for the biological tissues by intraoperative imaging. The experimental results of human blood in imaging system show the intraoperative imaging navigation system based on the near-infrared fluorescence properties of indocyanine green has high fluorescence induction, apparent distinct and better imaging quality, which indicates the feasibility of the design proposal.

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