中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (27): 5104-5107.doi: 10.3969/j.issn.1673-8225.2011.27.037

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

脂肪来源干细胞诱导表皮细胞化的研究现状与进展

江  波，廖  毅，童庭辉   

  1. 泸州医学院整形烧伤科，四川省泸州市   646000
  • 收稿日期:2011-01-21 修回日期:2011-03-18 出版日期:2011-07-02 发布日期:2011-07-02
  • 通讯作者: 廖毅，教授，硕士生导师，泸州医学院整形烧伤科，四川省泸州市 646000
  • 作者简介:江波★，男，1983年生，重庆市人，汉族，泸州医学院整形烧伤科在读硕士，主要从事烧伤创面修复研究。 jiangdabo1983@yahoo.cn

Research progress of adipose-derived stem cells inducing epidermal cells

Jiang Bo, Liao Yi, Tong Ting-hui   

  1. Department of Burn and Plastic Surgery, Luzhou Medical College, Luzhou  646000, Sichuan Province, China
  • Received:2011-01-21 Revised:2011-03-18 Online:2011-07-02 Published:2011-07-02
  • Contact: Liao Yi, Professor, Master’s supervisor, Department of Burn and Plastic Surgery, Luzhou Medical College, Luzhou 646000, Sichuan Province, China
  • About author:Jiang Bo★, Studying for master’s degree, Department of Burn and Plastic Surgery, Luzhou Medical College, Luzhou 646000, Sichuan Province, China jiangdabo1983@yahoo.cn

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306

被引次数

3

摘要：

背景：脂肪干细胞通过向表皮细胞进行诱导可以对难愈创面的修复提供理想的解决方法。
目的：通过分析总结近10年以来脂肪干细胞的研究方法和思路，期待能为脂肪干细胞诱导表皮细胞化提供总结和探索。
方法：由第一作者分别以“干细胞、脂肪干细胞”、“ADSCs 、adipose derived stem cells” 为检索词，应用计算机检索重庆维普(VIP)期刊全文数据库以及万方数据库2001-01/2010-10有关文章，纳入有关脂肪干细胞组织工程的文献。排除与研究目的无关和内容重复者。保留26篇文献做进一步分析。
结果及结论：脂肪干细胞作为一种种子细胞，有望在一定的条件下定向诱导分化成为表皮细胞，并且提高诱导分化率和扩增能力，最终达到临床治疗使用的目的。其具有的来源丰富、易于获得、有多向分化潜能、相容性好、对患者损伤小等特点无疑是其他众多间充质干细胞所无法比拟的。但同时，脂肪干细胞在无免疫力的移植受体上表现的肿瘤样无限增生特性，在进入临床试验前仍需要寻找并建立合适的动物模型进行长期观测以确定其移植后的安全性；其次，脂肪干细胞向表皮细胞诱导尚无一安全稳定并行之有效的培养、诱导方式；以及在批量提取生产脂肪干细胞的过程中，如何保障细胞质量的均一稳定性仍然有待进一步研究。

关键词: 脂肪干细胞, 表皮细胞化, 组织工程, 诱导, 综述文献

Abstract:

BACKGROUND: Adipose-derived stem cells inducing epidermal cells are enabled to provide ideal treatment for refractory wounds healing.
OBJECTIVE: To analyze and sum up the research methods and ideas regarding the adipose derived stem cells in recent 10 years, in a broader attempt to summarize and explore the way how adipose derived stem cells induce epidermal cells.
METHODS: A computer-based retrieval of VIP Periodical Full-text Database and Wanfang database from January 2001 to October 2010 was performed, with the keywords of ADSCs and adipose derived stem cells in English and Chinese. Articles related with the adipose stem cells tissue engineering were included. Those of irrelevant purpose and repetitive content were ruled out. Finally 26 literatures were summarized.
RESULTS AND CONCLUSION: As a kind of seed cells available, adipose derived stem cells could directionally induce and differentiate to epidermal cells under some conditions, and improve the ability to induce differentiation and proliferation, thus achieving the goals of clinical usage. Adipose derived stem cells are characterized by abundant sources, easy gain, multi-directional differentiation potentials, good compatibility and small injury to patients, which make it surpass other mesenchymal stem cells. However, adipose derived stem cells manifest infinite proliferation like tumor cells in nonimmune transplanting receptors. The security after transplantation should be observed on suitable animal models in a long term before clinical trial. Moreover, there’s no secure and stable way to cultivate and induce adipose derived stem cells effectively, and how to maintain the quality of cells stable in the process of the abstracting and producing adipose derived stem cells remains further researches.

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