中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (22): 4098-4102.doi: 10.3969/j.issn.1673-8225.2011.22.026

• 数字化骨科 digital orthopedics • 上一篇    下一篇

模型动物失神经支配及神经肌肉电刺激的可编程植入式神经肌肉电刺激器

宋  光，王  磊，任超世，沙  洪   

  1. 中国医学科学院、北京协和医学院生物医学工程研究所，生物信息检测与处理实验室，天津市  300192
  • 收稿日期:2011-03-06 修回日期:2011-04-03 出版日期:2011-05-28 发布日期:2011-05-28
  • 通讯作者: 沙洪，硕士，研究员，硕士研究生导师，中国医学科学院、北京协和医学院生物医学工程研究所，天津市300192 sha_hong_2000@hotmail.com
  • 作者简介:宋光★，男，1986年生，山西省天镇县人，汉族，中国医学科学院、北京协和医学院在读硕士，主要从事生理信号检测与硬件电路设计及信号处理等方面的研究。 song_job@163.com

A programmable and implantable neuromuscular electrical stimulator for denervated or neuromuscular electrical stimulation in animal models

Song Guang, Wang Lei, Ren Chao-shi, Sha Hong   

  1. Bioinformation Measurement and Processing Laboratory, Institute of Biomedical Engineering, Chinese Academy of Medical Science and Peking Union Medical College, Tianjin  300192, China
  • Received:2011-03-06 Revised:2011-04-03 Online:2011-05-28 Published:2011-05-28
  • Contact: Sha Hong, Master, Investigator, Master’s supervisor, Bioinformation Measurement and Processing Laboratory, Institute of Biomedical Engineering, Chinese Academy of Medical Science and Peking Union Medical College, Tianjin 300192, China sha_hong_2000@hotmail.com
  • About author:Song Guang★, Studying for master’s degree, Bioinformation Measurement and Processing Laboratory, Institute of Biomedical Engineering, Chinese Academy of Medical Science and Peking Union Medical College, Tianjin 300192, China song_job@163.com

PDF

423

被引次数

2

摘要：

背景：植入式神经肌肉电刺激器可用于研究功能性电刺激对动物失神经肌肉的作用机制，但体积偏大，功能单一。
目的：设计一种微型、参数可调的植入式神经肌肉电刺激器。
方法：基于红外通信技术，以MSP430为控制核心，采用低功耗设计，经体外控制器设置参数，产生电荷平衡的双相脉冲序列，可对神经或肌肉进行电刺激。
结果与结论：实验设计的刺激器可在体编程，能够灵活设置刺激电压幅值、频率、脉宽和间隔时间等参数。多参数的设置丰富了刺激协议选择性，可最小化对目标神经肌肉临近组织的不可预测刺激，优化了功耗设计，可确保实验动物的安全性。

关键词: 植入式电刺激器, 红外通信, 参数可调, 双相脉冲, 组织工程

Abstract:

BACKGROUND: Implantable neuromuscular electrical stimulator is a useful tool for the study how functional electrical stimulation works on denervated muscle. However, its volume is a little big and the function is single.
OBJECTIVE: To design an implantable micro-stimulator featuring adjustable parameters which can reach the requirement of animal pattern experiment through test and analysis.
METHODS: Based on infrared communication technology, taking MSP430 as controller and setting stimulation parameters by controller in vitro, it generates charge balanced bipolar pulses, and stimulates nerve or muscle via electrodes.
RESULTS AND CONCLUSION: The stimulator is programmable in vivo and all parameters, such as voltage amplitude, frequency, pulse width and rest time of the stimulation, can be set and changed flexibly. It enriches selectivity of stimulating protocol by setting parameters, so that the unpredictable stimulation to the tissue around the target neuromuscular is minimized, the design of current consumption is optimized and the safety of experimental animals is ensured.

中图分类号: