中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (20): 3662-3665.doi: 10.3969/j.issn.1673-8225.2011.20.013

• 组织构建实验造模 experimental modeling in tissue construction • 上一篇    下一篇

脊髓损伤继发骨质疏松大鼠椎骨的力学变化

孙树东1，高  明2，李新颖2，权铁刚2，马洪顺3   

  1. 1吉林大学第二医院，吉林省长春市130036
    2吉林大学中日联谊医院，吉林省长春市 130031
    3吉林大学南岭校区工程力学系，吉林省长春市 130022
  • 收稿日期:2010-11-12 修回日期:2010-12-16 出版日期:2011-05-14 发布日期:2011-05-14
  • 通讯作者: 孙树东，硕士，副教授，吉林大学第二医院，吉林省长春市130036 mahs@jlu.edu. cn
  • 作者简介:孙树东★，男，1964年生，吉林省扶余县人，汉族，2000年吉林大学毕业，硕士，副教授，主要从事骨科临床与生物力学研究。 mahs@jlu.edu. cn

Mechanical properties variations of rat vertebra osteoporosis secondary to spinal cord injury

Sun Shu-dong1, Gao Ming2, Li Xin-ying2, Quan Tie-gang2, Ma Hong-shun3   

  1. 1Second Hospital of Jilin University, Changchun  130036, Jilin Province, China
    2China-Japan Union Hospital of Jilin University, Changchun  130031, Jilin Province, China
    3Department of Engineering Mechanics, Nanling Campus, Jilin University, Changchun  130022, Jilin Province, China
  • Received:2010-11-12 Revised:2010-12-16 Online:2011-05-14 Published:2011-05-14
  • Contact: Sun Shu-dong★, Master, Associate professor, Second Hospital of Jilin University, Changchun 130036, Jilin Province, China mahs@jlu.edu.cn
  • About author:Sun Shu-dong★, Master, Associate professor, Second Hospital of Jilin University, Changchun 130036, Jilin Province, China mahs@jlu.edu.cn

PDF

343

被引次数

17

摘要：

背景：脊髓损伤造成下肢肌肉萎缩，久之引起骨质疏松，为了解脊髓损伤继发骨质疏松的发病机制，有必要对脊髓损伤继发骨质疏松动物模型骨进行生物力学性质研究。
目的：观察脊髓损伤所导致骨的力学变化。
方法：选用Wistar雄性大鼠66只，随机分为空白组和模型组。模型组大鼠于T10椎体水平剪开椎板损伤脊髓。损伤后11周解剖取大鼠L1~4椎骨，进行压缩实验、取L1~4椎骨进行扭转、冲击实验。
结果与结论：模型组压缩实验最大载荷、最大应力、最大应变，扭转实验最大转矩、最大扭转角、最大切应力，冲击实验最大冲击功、最大冲击韧性均小于空白组(P < 0.05)，说明脊髓损伤继发大鼠骨质疏松后大鼠椎骨压缩、扭转、冲击力学特性发生改变。

关键词: 脊髓损伤, 骨质疏松, 压缩, 扭转, 冲击, 大鼠

Abstract:

BACKGROUND: Spinal cord injury lead to muscular atrophy of lower extremity and evoke osteoporosis following a long duration. It is necessary to study the mechanical properties of animal models with osteoporosis secondary to spinal cord injury.
OBJECTIVE: To observe spinal cord injury-induced mechanical changes of vertebra.
METHODS: Totally 66 Wistar, male, rats were randomly divided into the control and model groups. Spinal cord was injured by cutting vertebral plate at T10 centrum horizontally. L1-4 vertebra was harvested at 11 weeks after model preparation for compression, torsion and impulse tests.
RESULTS AND CONCLUSION: Compared with the control group, the maximum load, maximum stress, maximum torque, maximum stress, maximum torsion angle, maximum impact energy, and maximum impact toughness of the model group were smaller (P < 0.05), suggesting that there are variations in compression, torsion and impulse features of rat vertebra osteoporosis secondary to spinal cord injury. 

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