中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (18): 3395-3397.doi: 10.3969/j.issn.1673-8225.2011.18.040

• 器官移植临床实践 clinical practice of organ transplantation • 上一篇    下一篇

老龄供者亲属活体肾移植疗效分析

王  凯，曲青山，苗书斋   

  1. 郑州人民医院器官移植科，河南省郑州市450003
  • 收稿日期:2010-11-01 修回日期:2011-01-15 出版日期:2011-04-30 发布日期:2011-04-30
  • 作者简介:王凯★，男，1982年生，河南省开封市人，汉族，2008年郑州大学毕业，硕士，医师，主要从事肾病、器官移植方面的研究。 hywangkai@126.com

Clinical effect analysisis of the elder living kidney donors and relatives kidney transplants

Wang Kai, Qu Qing-shan, Miao Shu-zhai   

  1. Department of Organ Transplantation, Zhengzhou People’s Hospital, Zhengzhou  450003, Henan Province, China
  • Received:2010-11-01 Revised:2011-01-15 Online:2011-04-30 Published:2011-04-30
  • About author:Wang Kai★, Master, Physician, Department of Organ Transplantation, Zhengzhou People’s Hospital, Zhengzhou 450003, Henan Province, China hywangkai@126.com

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摘要：

背景：近几年随着各项移植法规相继出台，亲属肾移植数量在国内多个移植中心呈逐渐增多趋势。目前国际上对活体供肾供者尚没有最大年龄的明确限制，由于供器官的极度短缺，国际上很多移植中心开始尝试老龄供者。
目的：探讨老龄供者亲属肾移植的临床疗效及应用特点。
方法：亲属活体肾移植65例按供肾者年龄分为2组：老龄组(n=16)：供者年龄≥55岁；对照组(n=49)：供者年龄<55岁。两组供者平素健康状况良好，心肝肺等重要脏器功能健全，无高血压及糖尿病，移植前查血肌酐清除率均在80 mL/min以上。两组基线资料相似。移植后6个月内进行随访，评价两组受者移植后的肾功能恢复及早期并发症发生情况。
结果与结论：移植后两组受者肾功能恢复良好，急性排斥反应、移植物功能延迟恢复等早期并发症发生率比较，差异无显著性意义(P > 0.05)。提示在目前肾源缺少的情况下，选择老龄供者进行亲属活体肾移植，只要严格供肾纳入标准，可以取得良好的治疗效果。

关键词: 老龄供者, 肾移植, 亲属, 活体移植, 疗效

Abstract:

BACKGROUND: In recent years with various transplant regulations were enacted, the number of relatives kidney transplants has increased in many transplantation centers at home. At present, there is no definite restriction about the oldest age to living body kidney donor in international. Due to the extreme shortage of organ transplants, in many international transplantation centers, they are trying for the elder donor.
OBJECTIVE: To investigate the clinical effects and application prospect of the elder living kidney donors and the relatives kidney transplants.
METHODS: According to the age, 65 patients with living donor kidney transplantation were divided into 2 groups: 16 cases in the aged group (donor age ≥ 55 years) and 49 cases in the control group (donor age < 55 years). The donors of the two groups were eucrasia, functions of heart, liver, lung were perfect, and without hypertension and diabetes mellitus. The creatinine clearance rates were above 80mL/min before transplantation. The baseline datas of two groups were similar. A follow-up at 6 months after transplantation was to evaluate the renal function recovery and early complications of the two groups.
RESULTS AND CONCLUSION: The renal functions of the two groups were recovered well. There was no significant difference in early complications of acute rejection, delaying recovery of the graft function (P > 0.05). Under the lack of source of kidney, the elder donors undergo living related renal transplantation according to strict donor kidney inclusion criteria, which can obtain good therapeutic efficacy.

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