中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (18): 3255-3258.doi: 10.3969/j.issn.1673-8225.2011.18.007

• 肝移植 liver transplantation • 上一篇    下一篇

盐酸戊乙奎醚对原位肝移植后急性肺损伤的保护效应

司建洛1，宋绍团1，昌  盛2   

  1. 1河南科技大学第一附属医院麻醉科，河南省洛阳市   471003
    2华中科技大学同济医学院附属同济医院器官移植研究所，湖北省武汉市   430030
  • 收稿日期:2010-11-20 修回日期:2011-01-24 出版日期:2011-04-30 发布日期:2011-04-30
  • 作者简介:司建洛★，男，1972年生，河南省洛阳市人，汉族，2004年首都医科大学毕业，硕士，主治医师，主要从事围术期器官保护的研究。 jianluo_si@sina.com

Protective effects of penequinine hydrochloride on acute lung injury induced by orthotopic liver transplantation

Si Jian-luo1, Song Shao-tuan1, Chang Sheng2   

  1. 1Department of Anesthesiology, First Affiliated Hospital, Henan University of Science and Technology, Luoyang  471003, Henan Province, China
    2Institute of Organic Transplantation, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan  430030, Hubei Province, China
  • Received:2010-11-20 Revised:2011-01-24 Online:2011-04-30 Published:2011-04-30
  • About author:Si Jian-luo★, Master, Attending physician, Department of Anesthesiology, First Affiliated Hospital, Henan University of Science and Technology, Luoyang 471003, Henan Province, China jianluo_si@sina.com

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325

被引次数

4

摘要：

背景：盐酸戊乙奎醚具有抗炎、细胞保护等作用，其对于肝移植后急性肺损伤的治疗效果尚不明确。
目的：验证盐酸戊乙奎醚对原位肝移植后急性肺损伤的保护效应。
方法：纳入原位肝移植后急性肺损伤患者35例，随机分为盐酸戊乙奎醚组和安慰剂对照组，双盲法连续3 d每隔24 h在常规综合治疗的基础上静脉给予盐酸戊乙奎醚0.05 mg/kg或等量生理盐水注射液。以酶联免疫吸附法观察两组治疗前，治疗后24，72 h血清白细胞介素8，10的质量浓度，根据动脉血气计算氧合指数，记录呼吸机的使用时间。
结果与结论：与对照组相比，盐酸戊乙奎醚组患者治疗后24 h和72 h的白细胞介素8质量浓度降低，白细胞介素10质量浓度升高，氧合指数升高，呼吸机使用时间缩短(P均 < 0.05)。提示盐酸戊乙奎醚能调控肝移植后急性肺损伤患者炎性因子的水平，改善动脉氧合，缩短呼吸机的使用时间。

关键词: 盐酸戊乙奎醚, 原位肝移植, 急性肺损伤, 白细胞介素8, 白细胞介素10

Abstract:

BACKGROUND: Penequinine hydrochloride can alleviate inflammatory response and protect against cell injury, but therapeutic effects were uncertainty on acute lung injury after orthotopic liver transplantation.
OBJECTIVE: To evaluate protective efficacy of intravenous penequinine hydrochloride on acute lung injury after orthotopic liver transplantation.
METHODS: Thirty-five patients with acute lung injury after orthotopic liver transplantation were randomly assigned to 2 groups: treatment group (n=17) and control group (n=18). On the base of routine comprehensive therapy, the patients received intravenous infusion with 0.05 mg/kg penequinine hydrochloride once a day for 3 days in the treatment group or with normal saline of same volume in the control group. Plasma interleukin (IL)-8, and IL-10 were measured and index of oxygenation was calculated before and 24, 72 hours after the treatment. Length of mechanical ventilation was recorded.
RESULTS AND CONCLUSION: Compared with the control group, the level of plasma IL-8 decreased significantly in the treatment group at 24 and 72 hours after the treatment, but the level of plasma IL-10 in the treatment group was significantly higher than that in the control group at the same time (P < 0.05). In the treatment group, the patients’ index of oxygenation was higher and length of mechanical ventilation was shorter than that in the control group (P < 0.05). These findings show that penequinine hydrochloride can regulate the level of inflammatory factors in patients with acute lung injury after orthotopic liver transplantation, improve arterial oxygenation and shorten the length of mechanical ventilation.

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